5055-72-1

Usage

Uses

Used in Rubber Industry:
1-Cyclohexyl-2-thiourea is used as a rubber accelerator for the vulcanization process in rubber production, catalyzing the crosslinking of rubber molecules to improve the strength and elasticity of the final product.
Used in Pharmaceutical Synthesis:
CTU serves as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new medicinal compounds.
Used as a Corrosion Inhibitor:
In industrial settings, 1-Cyclohexyl-2-thiourea is utilized as a corrosion inhibitor, protecting metal surfaces from degradation and extending their service life.
Used in Metal Surface Treatment:
CTU is employed in the treatment of metal surfaces, enhancing their durability and resistance to environmental factors.
It is crucial to handle 1-Cyclohexyl-2-thiourea with care due to its potential hazards to health and the environment if mismanaged.

InChI:InChI=1/C7H14N2S/c8-7(10)9-6-4-2-1-3-5-6/h6H,1-5H2,(H3,8,9,10)

Upstream product

• 625-57-0 O-ethyl thiocarbamate 
• 108-91-8 cyclohexylamine 
• 27248-25-5 4-isothiocyanato-4-methylpentan-2-one 
• 115983-15-8 N-(2-butenoyl)-N'-(cyclohexyl)thiourea 
• 98-88-4 benzoyl chloride 
• 43009-21-8 Cyclohexyl-dithiocarbamic acid; compound with triethyl-amine 
• 4921-92-0 TM-2-97 
• 17356-08-0 thiourea 
• 931-53-3 Cyclohexyl isocyanide 
• 13037-17-7 Cyclohexyldithiocarbamidsaeure-methylester 
• 3173-53-3 Cyclohexyl isocyanate 
• 95-55-6 2-amino-phenol 
• 1212-29-9 1,3-dicyclohexylthiourea 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 4421-48-1 N-cyanocyclohexylamine 
• 3753-40-0 N-cyclohexyl-S-methyl-isothiourea; hydriodide 
• 3621-74-7 3-cyclohexyl-2-imino-thiazolidine-4,5-dione 
• 2289-76-1 cyclohexyl-(4,5-dimethyl-thiazol-2-yl)-amine 
• 34631-45-3 cyclohexyl-(4-ethyl-thiazol-2-yl)-amine 
• 1438-45-5 N‐cyclohexylthiazol‐2‐amine 
• 76758-05-9 1-Cyclohexyl-3-(toluene-4-sulfonylmethyl)-thiourea 
• 84669-95-4 3-Bromo-3-methyl-2-oxo-azetidine-1-carbothioic acid cyclohexylamide 
• 189572-02-9 tert-butyl N-(cyclohexylcarbamothioyl)carbamate 
• 36997-96-3 N-acetyl-N'-cyclohexyl-thiourea 
• 72320-98-0 1-cyclohexyl-2-methyl-isothiourea 
• 20974-13-4 1-cyclohexyl-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 76805-84-0 2-cyclohexylamino-4-dimethylamino-1,3-thiazabuta-1,3-diene 
• 1497250-05-1 C₁₀H₁₆N₂S*BrH 

Relevant academic research and scientific papers

Iron-mediated desulphurization approach: synthesis of cyanamides and their conversions

The iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology. All the reactions are rapid, facile, and accomplished at room temperature. A variety of substrates readily underwent the optimized reaction conditions to provide their respective target products in good to excellent yields. Furthermore, we have confirmed that no other by-products could be identified during our experimental reaction process. Graphical abstract: Iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology.[Figure not available: see fulltext.].

Convenient Multicomponent One-Pot Synthesis of 2-Iminothiazolines and 2-Aminothiazoles Using Elemental Sulfur Under Aqueous Conditions

Herein, we present a novel one-pot aqueous reaction for the synthesis of 2-iminothiazolines and 2-aminothiazoles using isocyanides, amines, sulfur, and 2′-bromoacetophenones. The three-component preparation of thioureas is followed by the one-pot cyclization leading to the heterocyclic product. This efficient and mild procedure features excellent step- and atom-economy and enables the chromatography-free preparation of diversely substituted 2-iminothiazoline and 2-aminothiazole derivatives.

Green and efficient synthesis of thioureas, ureas, primary: O -thiocarbamates, and carbamates in deep eutectic solvent/catalyst systems using thiourea and urea

An efficient and general catalysis process was developed for the direct preparation of various primary O-thiocarbamates/carbamates as well as monosubstituted thioureas/ureas by using thiourea/urea as biocompatible thiocarbonyl (carbonyl) sources. This procedure used choline chloride/tin(ii) chloride [ChCl][SnCl2]2 with a dual role as a green catalyst and reaction medium to afford the desired products in moderate to excellent yields. Moreover, the DES can be easily recovered and reused for seven cycles with no significant loss in its activity. Besides, the method shows very good performance for synthesizing the desired products on a large scale.

Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach ?

Cystic fibrosis (CF) is a multiorgan disease caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR). In addition to respiratory impairment due to mucus accumulation, viruses and bacteria trigger acute pulmonary exacerbations, accelerating disease progression and mortality rate. Treatment complexity increases with patients' age, and simplifying the therapeutic regimen represents one of the key priorities in CF. We have recently reported the discovery of multitarget compounds able to "kill two birds with one stone" by targeting F508del-CFTR and PI4KIIIβ and thus acting simultaneously as CFTR correctors and broad-spectrum enterovirus (EV) inhibitors. Starting from these preliminary results, we report herein a hit-to-lead optimization and multidimensional structure-activity relationship (SAR) study that led to compound 23a. This compound showed good antiviral and F508del-CFTR correction potency, additivity/synergy with lumacaftor, and a promising in vitro absorption, distribution, metabolism, and excretion (ADME) profile. It was well tolerated in vivo with no sign of acute toxicity and histological alterations in key biodistribution organs.

Cobalt-promoted one-pot reaction of isothiocyanates toward the synthesis of aryl/alkylcyanamides and substituted tetrazoles

[Figure not available: see fulltext.] The synthesis of cyanamides and tetrazoles from isothiocyanates through tandem reaction using cobalt catalyst has been demonstrated. In the case of tetrazole preparation, the reaction involved addition/desulfurization/nucleophilic addition/electrocyclization, whereas aromatic cyanamides were constructed from isothiocyanates through addition/desulfurization. Cheap cobalt sulfate was used for the synthesis of various cyanamides and tetrazoles. In addition, cobalt catalyst was found to be desulfurization reagent that has not been previously reported. The final products have been obtained from starting precursors in good to high yield.

A novel one-pot synthesis of isothiocyanates and cyanamides from dithiocarbamate salts using environmentally benign reagent tetrapropylammonium tribromide

A highly efficient and simple protocol for the synthesis of isothiocyanates and cyanamides from their respective amines in the presence of a mild, efficient, and non-toxic reagent tetrapropylammonium tribromide is described. High environmental acceptability of the reagents, cost effectiveness and high yields are the important attributes of this methodology.

Design, synthesis and biological evaluation of novel HSP70 inhibitors: N, N′-disubstituted thiourea derivatives

As novel heat shock protein 70 (HSP70) inhibitors, N, N′-disubstituted thiourea derivatives were designed and synthesized based on the X-ray structure of the ATPase domain (nucleotide binding domain, NBD). An ATPase activity inhibition assay revealed that these compounds effectively inhibited HSP70 ATPase activity. The results revealed that the compounds 370/371/374/379/380//392/394/397/404/405 and 407 can inhibit the HSP70 ATPase turnover with high percentages of inhibition: 50.42, 38.46, 50.45, 44.12, 47.13, 50.50, 40.95, 65.36, 46.23, 35.78, and 58.37 in 200 μM, respectively. Significant synergies with lapatinib were observed for compound 379 and compound 405 in the BT474 breast cancer cell line. A structure-function analysis revealed that most of the thiourea derivatives exhibited cooperative action with lapatinib in the BT474 cancer cell line and the BT/LapR1.0 lapatinib-resistant cell line. HSP70 inhibitors may be developed as synergetic drugs in drug-resistant cancer therapy.

An efficient methodology for the synthesis of thioureas from amine mediated by a cobalt source

The cheap, readily available and air stable cobalt catalyst was used as the desulfurization agent for the conversion of aniline to thioureas in one pot three step reaction under mild reaction conditions. The reactions are rapid and facile and accomplished at room temperature.

Evaluation of aminohydantoins as a novel class of antimalarial agents

Given the threat of drug resistance, there is an acute need for new classes of antimalarial agents that act via a unique mechanism of action relative to currently used drugs. We have identified a set of druglike compounds within the Tres Cantos Anti-Malar

COMPOSITIONS AND METHODS FOR THE TREATMENT OF MALARIA

The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided.