50563-23-0Relevant academic research and scientific papers
Cyclic versus hemi-bastadins. Pleiotropic anti-cancer effects: From apoptosis to anti-angiogenic and anti-migratory effects
Mathieu, Veronique,Wauthoz, Nathalie,Lefranc, Florence,Niemann, Hendrik,Amighi, Karim,Kiss, Robert,Proksch, Peter
, p. 3543 - 3561 (2013)
Bastadins-6, -9 and -16 isolated from the marine sponge Ianthella basta displayed in vitro cytostatic and/or cytotoxic effects in six human and mouse cancer cell lines. The in vitro growth inhibitory effects of these bastadins were similar in cancer cell
N-terminal α-amino group modification of peptides by an oxime formation-exchange reaction sequence
Kung, Karen Ka-Yan,Wong, Kong-Fan,Leung, King-Chi,Wong, Man-Kin
, p. 6888 - 6890 (2013)
A site-specific and efficient method for N-terminal modification of peptides using oxone for selective oxidation of N-terminal α-amino groups of peptides to oximes followed by transoximation with O-substituted hydroxylamines has been developed.
Synthesis of spiroisoxazolines via TEMPO/NaNO2-catalyzed aerobic oxidative dearomatization
Chen, Dengfeng,Wang, Yaming,Cai, Xu-Min,Cao, Xiaoji,Jiang, Ping,Wang, Fei,Huang, Shenlin
supporting information, p. 6847 - 6851 (2020/09/15)
A catalytic, aerobic oxidative dearomatization protocol has been developed for the preparation of spiroisoxazline scaffolds from oximes using TEMPO and NaNO2 as the catalyst and O2 as the sole oxidant. This dearomatization methodology features its mild reaction conditions, good functional group tolerance, and an unprecedented broad substrate scope, encompassing phenols, aryl ethers, thiophenols, aryl sulfides, etc.
Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge
Kotoku, Naoyuki,Tsujita, Hiroaki,Hiramatsu, Atsushi,Mori, Chinatsu,Koizumi, Noriko,Kobayashi, Motomasa
, p. 7211 - 7218 (2007/10/03)
An efficient total synthesis of bastadin 6 (1), a cyclic tetramer of brominated tyrosine derivatives from the marine sponge, Ianthella basta, with selective anti-angiogenic activity, was accomplished. We developed a novel Ce(IV)-mediated oxidative couplin
