50593-69-6

Basic information

• Product Name: 4,7-DICHLORO-2-METHYLQUINOLINE
• Synonyms: 4,7-DICHLORO-2-METHYLQUINOLINE;4,7-DICHLOROQUINALDINE;2-Methyl-4,7-dichloroquinoline
• CAS NO: 50593-69-6
• Molecular Formula: C₁₀H₇Cl₂N
• Molecular Weight: 212.08
• Mol File: 50593-69-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 103.5-104 °C
• Boiling Point: 301.3 °C at 760 mmHg
• Flash Point: 164.4 °C
• Appearance: /
• Density: 1.351 g/cm³
• Vapor Pressure: 0.0019mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: 2-8°C
• PKA: 2.81±0.50(Predicted)
• CAS DataBase Reference: 4,7-DICHLORO-2-METHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,7-DICHLORO-2-METHYLQUINOLINE(50593-69-6)
• EPA Substance Registry System: 4,7-DICHLORO-2-METHYLQUINOLINE(50593-69-6)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 50593-69-6(Hazardous Substances Data)

Usage

General Description

4,7-Dichloro-2-methylquinoline is a synthetic organic compound with the molecular formula C10H6Cl2N. It is a chlorinated derivative of quinoline, which is a heterocyclic aromatic compound commonly found in coal tar and tobacco smoke. 4,7-Dichloro-2-methylquinoline has a pale yellow color and a strong odor. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 4,7-Dichloro-2-methylquinoline has shown potential biological activity as an anti-malarial and anti-cancer agent. However, its use and handling require proper safety precautions due to its toxic and irritating properties. Overall, 4,7-Dichloro-2-methylquinoline is an important chemical in the field of organic synthesis and drug development.

InChI:InChI=1/C10H7Cl2N/c1-6-4-9(12)8-3-2-7(11)5-10(8)13-6/h2-5H,1H3

Upstream product

• 15644-88-9 7-chloro-4-hydroxy-2-methylquinoline 
• 4964-78-7 7-chloro-2-methylquinoline 1-oxide 
• 108-42-9 3-chloro-aniline 
• 63010-73-1 ethyl β-(3-chloroanilino)crotonate 
• 1077-74-3 4,7-dichloroquinoline 1-oxide 
• 75-16-1 methylmagnesium bromide 
• 4965-33-7 2-methyl-7-chloroquinoline 
• 63010-73-1 ethyl 3-(3-chloro)anilino-2-butenoate 

Downstream Products

• 6907-57-9 4-(7-chloro-2-methyl-quinolin-4-ylamino)-phenol 
• 101439-49-0 (E)-4,7-dichloro-2-styrylquinoline 
• 855935-07-8 (7-chloro-2-methyl-[4]quinolylmercapto)-acetic acid 
• 31432-68-5 4,7-dichloro-2-[2-(5-nitro-furan-2-yl)-vinyl]-quinoline 
• 31432-69-6 4,7-Dichloro-2-<4'-(5-nitro-2-furyl)-1',3'-butadienyl>quinoline 
• 102374-64-1 4-(7-chloro-2-methylquinolin-4-ylamino)-2-((diethylamino)methyl)phenol 
• 1446350-20-4 N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)methanesulfonamide 
• 1417177-57-1 N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-3,5-dimethylbenzenesulfonamide 
• 1417177-56-0 N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-5-chlorothiophene-2-sulfonamide 
• 1446350-19-1 N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-2,4-dinitrobenzenesulfonamide 
• 1446350-18-0 N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl) thiophene-2-sulfonamide 
• 1446350-17-9 N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-3,4-dichlorobenzenesulfonamide 
• 1446350-16-8 N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-3,5-dichlorobenzenesulfonamide 
• 1446350-15-7 N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)naphthalene-1-sulfonamide 

Relevant articles and documents

Antibacterial activity and fluorescence properties of 4,7-dichloro-2-quinolinemethylacrylate

Currently, some quinoline-based anticancer drugs are successful repurposed for treatment of bacterial infections. This study assessed the antibacterial activity of the new anticancer compound 4,7-dichloro-2-quinolinemethylacrylate (AQM) against bacteria o

Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N -Heterocycles from n -oxides

A one-step transformation of heterocyclic N-oxides to 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles is described. The success of this broad-scope methodology hinges on the combination of copper catalysis and activation by lithium fluoride or magnesium chloride. The utility of this method for the late-stage modification of complex N-heterocycles is exemplified by facile syntheses of new structural analogues of several antimalarial, antimicrobial, and fungicidal agents.

N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.