63010-73-1

Basic information

• Product Name: 2-Butenoic acid, 3-[(3-chlorophenyl)amino]-, ethyl ester
• CAS NO: 63010-73-1
• Molecular Formula: C12H14ClNO2
• Molecular Weight: 239.702
• Mol File: 63010-73-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 3-[(3-chlorophenyl)amino]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 3-[(3-chlorophenyl)amino]-, ethyl ester(63010-73-1)
• EPA Substance Registry System: 2-Butenoic acid, 3-[(3-chlorophenyl)amino]-, ethyl ester(63010-73-1)

Safety Data

• Hazardous Substances Data: 63010-73-1(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 108-42-9 3-chloro-aniline 

Downstream Products

• 15644-88-9 7-chloro-4-hydroxy-2-methylquinoline 
• 50593-69-6 4,7-dichloro-2-methylquinoline 
• 97892-66-5 2-metil-4-idrazino-7-clorochinolina 
• 5165-46-8 1-(3-Chloro-phenyl)-5-hydroxy-2-methyl-1H-indole-3-carboxylic acid ethyl ester 
• 15644-87-8 5-chloro-4-hydroxy-2-methylquinoline 

Relevant articles and documents

Facile one-pot multicomponent synthesis of highly functionalized tetrahydropyridines using thiamine hydrochloride as an organocatalyst

Thiamine hydrochloride (VitB1) has been found to be an efficient catalyst for the multicomponent synthesis of highly functionalized tetrahydropyridines from the reaction of β-ketoester, aromatic aldehydes and anilines. VitB1 is easily available, cheap, and eco benign.

Synthesis of 3 H -Pyrrolo[2,3- c ]quinoline by Sequential i 2 -Promoted Cyclization/Staudinger/Aza-Wittig/Dehydroaromatization Reaction

A facile synthetic approach to access of 3 H -pyrrolo[2,3- c ]quinoline derivatives has been achieved by a sequential I 2 -promoted cyclization/Staudinger/aza-Wittig/dehydroaromatization reaction. The targeted products were received in moderate

N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.