50600-29-8

Upstream product

• 22440-35-3 2-phenyl-3-p-tolyl-oxirane 
• 66749-63-1 α,α'-diacetoxy-4-methyl-bibenzyl 
• 53172-92-2 α-trimethylsilyl-α-trimethylsiloxytoluene 
• 104-87-0 4-methyl-benzaldehyde 
• 100-42-5 styrene 
• 624-31-7 4-tolyl iodide 
• 100-52-7 benzaldehyde 
• 2431-00-7 p-methylbenzil 
• 589-18-4 4-Methylbenzyl alcohol 
• 100461-32-3 meso-4-methylstilbene dibromide 

Downstream Products

• 50600-30-1 2-(4-methylphenyl)-2-(phenyl)acetaldehyde 
• 104-87-0 4-methyl-benzaldehyde 

Relevant academic research and scientific papers

Oxidative and Redox-Neutral Approaches to Symmetrical Diamines and Diols by Single Electron Transfer/Hydrogen Atom Transfer Synergistic Catalysis

Homocoupling reactions of benzylamines and benzyl alcohols were examined under synergistic catalysis conditions with a photoredox catalyst and thiobenzoic acid as a hydrogen atom abstractor. When pivalaldehyde was used as an electron acceptor, oxidative dimerization proceeded selectively, whereas the use of benzaldehydes or iminium ions as electron acceptors resulted in redox-neutral coupling. These reactions afforded symmetrical 1,2-diamines and 1,2-diols in good yields.

The enhanced asymmetric hydrogenation of unsymmetrical benzils to hydrobenzoin catalyzed by organosoluble zirconium phosphonate-immobilized ruthenium catalyst

In this article, a successful design on translating a heterogeneous catalysis of chiral zirconium phosphonate-supported ruthenium catalyst into a homogeneous system was developed by the covalent attachment of chiral (R,R)-1,2-diphenyl-ethylenediamine [(R,R)-DPEN] into the backbone of zirconium phosphonate with the different arm lengths (n = 2, 4, 6) and immobilization of [RuCl2(p-cymene)]2. Their catalytic performances in the homogeneous asymmetric transfer hydrogenation of unsymmetrical benzils with m- and p-substituents were enhanced, and the excellent activities (>97.1% conv.), diastereomeric and enantiomeric purities (syn/anti = 11.0-29.4, 91.8-99.2%ee syn) were achieved. These homogeneous supported Ru catalysts could be quantitatively and readily recovered by addition of ethyl acetate and centrifugation by solid/liquid separation, and be reused for five times without significant loss of their catalytic performances with 97.0% conv.; 95.6% syn and syn/anti = 20.7.

Stereoselective synthesis of optically active hydrobenzoins via asymmetric hydrogenation of benzils with Ru(OTf)(TsDPEN)(I·6- cymene) as the pre-catalyst

Optically active hydrobenzoins are very important building blocks for further derivation of biologically active complexes, natural products, and pharmaceutical compounds. In this paper, A practical approach has been developed for asymmetric hydrogenation

A convenient synthesis of unsymmetrical pinacols by coupling of structurally similar aromatic aldehydes mediated by low-valent titanium

The one-pot, selective cross pinacol-type couplings between two structurally similar aromatic aldehydes promoted by low-valent titanium generated unsymmetrical pinacols in moderate to good isolated yields in an erythrolthreo ratio of up to 91:9. This synt

Multifunctional catalyst useful in the synthesis of chiral vicinal diols and process for the preparation thereof, and process for the preparation of chiral vicinal diols using said multifunctional catalysts

The present invention relates to a multifunctional reusable catalyst and to a process for the preparation thereof on a single matrix of the support to perform multicomponent reaction in a single pot. The multifunctional catalysts of the invention are usef

Multifunctional catalyst useful in the synthesis of chiral vicinal diols and process for the preparation thereof

The present invention relates to a multifunctional reusable catalyst and to a process for the preparation thereof on a single matrix of the support to perform multicomponent reaction in a single pot. The multifunctional catalysts of the invention are useful for the synthesis of chiral vicinal diols by tandem and / or simultaneous reactions involving Heck coupling, N-oxidation and AD reaction of olefins in presence of cinchona alkaloid compounds both as an native one and immobilized one in the said matrix support. This invention also relates to a process for preparing vicinal diols by asymmetric dihydroxylation of olefins in presence of cinchona alkaloid compounds employing reusable multifunctional catalysts as heterogeneous catalysts in place of soluble osmium catalysts.

Mg-promoted reductive cross coupling of carbonyl compounds with trimethylsilyl chloride

Mg-promoted cross-coupling of aromatic carbonyl compounds with trimethylsilyl chloride (TMSCl) in DMF at room temperature brought about reductive carbon-silicon bond formation to give the corresponding α-trimethylsilylalkyl trimethylsilyl ethers selectively in good yields.The reaction may be initiated through electron transfer from Mg metal to the carbonyl compounds.

Anionic Zirconaoxiranes as Nucleophilic Aldehyde Equivalents. Application to Intermolecular Pinacol Cross Coupling

Selective intermolecular pinacol cross coupling is achieved by reaction of anionic zirconaoxiranes with aromatic aldehydes and ketones, thereby providing an efficient route to unsymmetrical vicinal diols.