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Usage

Uses

Used in Flavoring and Fragrance Industry:
4-N-Heptylbenzaldehyde is utilized as a flavoring agent and fragrance in the food and cosmetic industries, where it imparts a sweet, almond-like aroma to products.
Used in Perfumery:
In the production of perfumes and other scented products, 4-N-heptylbenzaldehyde is used to enhance the scent profile and provide a unique, pleasant aroma.
Used in Pharmaceutical Industry:
4-N-Heptylbenzaldehyde has potential applications in the pharmaceutical industry, although specific uses are not detailed in the provided materials.
Used in Organic Synthesis:
4-N-HEPTYLBENZALDEHYDE can also be employed in organic synthesis for the creation of various chemical products, although the exact applications are not specified in the provided materials.
It is important to handle 4-N-heptylbenzaldehyde with care due to its potential harmful effects if ingested or inhaled, and its ability to cause skin and eye irritation.

Upstream product

• 542-88-1 bis(2-chloromethyl)ether 
• 1078-71-3 heptylbenzene 
• 79-37-8 oxalyl dichloride 
• 50606-96-7 4-heptylbenzoyl chloride 
• 4885-02-3 Dichloromethyl methyl ether 
• 171627-60-4 4-heptylbenzyl alcohol 
• 4282-40-0 1-Iodoheptane 
• 1122-91-4 4-bromo-benzaldehyde 
• 121866-31-7 4-hept-1-ynyl-benzaldehyde 
• 827028-05-7 4-hept-1-ynyl-benzoic acid ethyl ester 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 628-71-7 1-Heptyne 
• 100-97-0 hexamethylenetetramine 
• 220664-58-4 p-heptylbenzoic acid ethyl ester 

Downstream Products

• 57045-20-2 p-Heptylzimtsaeure 
• 60982-60-7 4-Octyloxy-4'-heptyl-α-cyanstilben 
• 81220-95-3 5-Heptyl-2-(4-heptyl-phenyl)-[1,3]dioxane 
• 81220-95-3 5-Heptyl-2-(4-heptyl-phenyl)-[1,3]dioxane 
• 1426121-83-6 C₃₆H₅₈N₂ 
• 1456602-11-1 5-(2-(4'-fluoro-N-methylbiphenyl-4-ylsulfonamido)-N-(4-heptylbenzyl)acetamido)-2-hydroxybenzoic acid 
• 1456602-61-1 5-(N-(4-heptylbenzyl)-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)-2-hydroxybenzoic acid 

Relevant academic research and scientific papers

Antimycobacterial activity evaluation, time-kill kinetic and 3D-QSAR study of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives

A series of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives were synthesized and evaluated for their antitubercular activity. Some of the compounds exhibited potent activity against Mycobacterium tuberculosis H37Rv. One of the compound having t-butyl at para position of the benzene ring showed excellent activity even better than the standard drug ethambutol with MIC value 1.1 ± 0.2 μM. The time-kill kinetics study of two most active compounds showed rapid killing of the M. tuberculosis within 4 days. Additionally atom-based quantitative structure-activity relationship (QSAR) model was developed that gave a statistically satisfying result (R2) = 0.92, Q2 = 0.75, Pearson-R = 0.96 and effectively predicts the anti-tuberculosis activity of training and test set compounds.

Zn-mediated, Pd-catalyzed cross-couplings in water at room temperature without prior formation of organozinc reagents

(Chemical Equation Presented) Mix in water, stir. That is all that is required in this new approach to sp3-sp2 cross-couplings between an alkyl iodide and an aryl bromide, both potentially bearing functionality. They react under cata

Orthoamide, LX [1]. N,N,N',N'-Tetraformylhydrazine- a Formylation Agent for Aromatic Compounds of Wide Scope

The reagent system formed from N,N,N',N'-tetraformylhydrazine (3) and aluminum chloride allows the formylation of aromatic compounds. The scope of the method is comparable with the Olah formylation and the Gross-Rieche procedure, since benzene and fluorobenzene can be formylated. Two formyl groups are transferred from 3 to the aromatic nuclei when a molar ratio 4:1:4 (aluminum chloride/3/aromatic compound) is chosen.

Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships

Sphingosine-1-phosphate (S1P) is an intracellular second messenger and an extracellular mediator through endothelial differentiation gene (EDG) receptors, which are a novel class of G-protein-coupled receptors. Although EDG has attracted much attention because of its various roles, no selective agonists or antagonists have yet been developed. This could account for the delay in clarifying the physiological roles of members of the EDG family. Because precise structural information on EDG receptors is not yet available, pharmacophore models were generated based on structural information for S1P using the rational drug design software Catalyst. Novel antagonists, 2-alkylthiazolidine-4-carboxylic acids, were retrieved from a three-dimensional database search using the pharmacophore models, and these showed activity for EDG3. On the basis of their nonphosphoric acid structure, more potent antagonists, 2-(m- or p-heptylphenyl)thiazolidine-4-carboxylic acid, were developed.

Synthesis of p-Alkyl-, p-Alkoxy-, and p-Acyloxycinnamates with trans-4-Phenylcyclohexyl and 4-Biphenylyl Fragments and Their Mesomorphic Properties

Acylation of trans-4-phenylcyclohexanol and p-cyano-p'-hydroxybiphenyl with p-n-alkyl-, p-n-alkoxy-, and p-n-alkanoyloxycinnamoyl chlorides yields corresponding cinnamates.

Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia

α-Phosphonosulfonate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula STR1 wherein R2 is OR5 or R5a ; R3 and R5 are independently H, alkyl, arylalkyl, aryl or cycloalkyl; R5a is H, alkyl, arylalkyl or aryl; R4 is H, alkyl, aryl, arylalkyl, or cycloalkyl;, Z is H, halogen, lower alkyl or lower alkenyl; and R1 is a lipophilic group which contains at least 7 carbons and is alkyl, alkenyl, alkynyl, mixed alkenyl-alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, cycloheteroalkyl, cycloheteroalkylalkyl; as further defined above; including pharmaceutically acceptable salts and or prodrug esters of the phosphonic (phosphinic) and/or sulfonic acids.

Phenyl acetylenic acetals

Phenyl acetylenic acetals and thioacetals and their use in the treatment of allergy, asthma, inflammation, arthritis, hyperproliferative skin disease, psoriasis or contact dermatitis are disclosed. Also disclosed are intermediates useful for producing sai

New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships

(p-Amylcinnamoyl)anthranilic acid (3a) had moderate antagonist activities against LTD4-induced smooth muscle contraction on guinea pig ileum and LTC4-induced bronchoconstriction in anesthetized guinea pigs. Modifications were made in the hydrophobic part (cinnamoyl moiety) and the hydrophilic part (anthranilate moiety) of 3a. A series of 8-(benzoylamino)-2-tetrazol-5-yl-1,4-benzodioxans and 8-(benzoylamino)-2-tetrazol-5-yl-4-oxo-4H-1-benzopyrans were revealed to be potent antagonists of leukotrienes C4 and D4. Among both series, ONO-RS-347 (18k) and ONO-RS411 (19h) were the most potent and orally active antagonists, respectively. Structure-activity relationships are discussed.

Synthesis of Unbranched 4-Alkylbenzaldehydes

The preparation of unbranched 4-alkylbenzaldehydes free of positional and branched-chain isomers by different methods is described.A one-step preparation of the aldehydes is reported which involves the direct hydrogenation of a Friedel-Craft's complex in the presence of Pd/C catalyst.

LOW-MELTING NEMATIC 4,4 prime -BIS-(ALKYLBENZAL)-2-CHLORO-1,4-PHENYLENEDIAMINES.

A series of 4,4 prime -bis(alkylbenzal)-2-chloro-1,4-phenylenediamines were prepared and their mesomorphic behavior characterized. All homologues showed nematic behavior with broad mesophases and rather low-melting points. The mesomorphic behavior is compared with that obtained from the 4,4 prime -bis-(alkoxybenzal)-1,4-phenylenediamine series and the 4,4 prime -bis-(alkoxybenzal)-2-chloro-1,4-phenylenediamine series.