83685-71-6

Upstream product

• 50611-92-2 3β-benzoyloxycholest-5-ene-4-one 
• 604-32-0 cholesteryl benzoate 
• 83685-71-6 3β-benzoyloxy-4β-hydroxy-5-cholestene 
• 50611-92-2 Benzoic acid (3S,8S,9S,10R,13R,14S)-17-(1,5-dimethyl-hexyl)-10,13-dimethyl-4-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 57-88-5 cholesterol 

Downstream Products

• 50611-92-2 3β-benzoyloxycholest-5-ene-4-one 
• 34310-86-6 cholest-5-ene-3β,4β-diol 
• 17320-10-4 4β-hydroxycholesterol 

Relevant academic research and scientific papers

Synthesis of [D4]- and [D7]-4β- hydroxycholesterols for use in a novel drug-drug interaction assay

Cytochrome P450 3A (CYP3A) enzymes are involved in the metabolism of over half of today's prescription drugs. As a result, drugs metabolized by CYP3A have a risk of drug-drug interactions (DDIs). Recent studies have shown the potential to use 4β-hydroxych

Oxidation with selenium dioxide: The first report of solvent-selective steroidal aromatization, efficient access to 4β,7α-dihydroxy steroids, and syntheses of natural diaromatic ergosterols

Selenium dioxide oxidation of cholesterol reveals a solvent-dependent product selectivity and facile one-pot synthesis of three derivatives, including aromatic analogues of naturally occurring ergosterol. Efficient access to 4β,7α-dihydroxy cholesterol is

Stereochemistry of the Reduction of 3β-Benzoyloxycholest-5-en-4-one with Sodium Borohydride

Reduction of 3β-benzoyloxycholest-5-en-4-one (3) with sodium borohydride under various conditions affords only minor amounts of 3β-benzoyloxycholest-5-en-4β-ol (2a).The major product is the 4α-isomer (6).Using sodium borodeuteride it has been shown that t

Lanthanoids in Organic Synthesis. 6. The Reduction of α-Enones by Sodium Borohydride in the Presence of Lanthanoid Chlorides: Synthetic and Mechanistic Aspects

Lanthanoid chlorides (LnCl3) are efficient catalysts for the regioselective 1,2-reduction of α-enones by NaBH4 in methanol solution.Optimal conditions of this reaction have been determined.A mechanistic interpretation depicting the role of the Ln3+ ions is given.The major effect of Ln3+ is the catalysis of BH4- decomposition by the hydroxylic solvent to afford alkoxyborohydrides, which may be responsible for the observed regioselectivity.The stereoselectivity of the process is also modified by the presence of the Ln3+ ions, in that axial attack of cyclohexanone systems is enhanced.