50624-25-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Hydroxy-4-methyl-pent-2-ynoic acid is used as a starting material for the synthesis of various pharmaceuticals due to its unique structure and reactivity, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 4-hydroxy-4-methyl-pent-2-ynoic acid serves as a key component in the synthesis of agrochemicals, aiding in the development of effective pesticides and other agricultural products.
Used in Specialty Chemicals Production:
4-Hydroxy-4-methyl-pent-2-ynoic acid is utilized as a building block in the preparation of specialty chemicals, enhancing the properties and performance of various chemical products.
Used in Flavors and Fragrances Industry:
This organic acid is employed in the production of flavors and fragrances, leveraging its unique chemical properties to create distinct scents and tastes for various applications.
Used in Drug Discovery and Development:
Due to its high reactivity and unique structure, 4-hydroxy-4-methyl-pent-2-ynoic acid has potential applications in drug discovery and development, offering new avenues for the creation of innovative pharmaceutical compounds.

InChI:InChI=1/C6H8O3/c1-6(2,9)4-3-5(7)8/h9H,1-2H3,(H,7,8)

Upstream product

• 79-22-1 methyl chloroformate 
• 124-38-9 carbon dioxide 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 109-72-8 n-butyllithium 
• 129913-03-7 4-methyl-4-tert-butylperoxy-2-pentynoic acid 
• 52258-96-5 3-methyl-3-tert-butylperoxy-1-butyne 
• 67-64-1 acetone 
• 471-25-0 Propiolic acid 

Downstream Products

• 3123-97-5 dihydro-5,5-dimethyl-2(3H)-furanone 
• 69088-96-6 2-methyl-4-(3-aminophenyl)-3-butyn-2-ol 
• 299912-59-7 3-butyn-2-ol, 4-[3-[[6,7-bis(2-methoxyethoxy)-4-quinazolinyl]amine]phenyl]-2-methyl, hydrochloride 
• 33432-52-9 2-methyl-4-(3-nitrophenyl)-3-butyn-2-ol 
• 104581-30-8 2-methyl-4-(3-acetylaminophenyl)-3-butyn-2-ol 
• 79756-91-5 2-methyl-4-(4-methylphenyl)-3-butyn-2-ol 

Relevant academic research and scientific papers

OXAZOLIDINONE HYDROXAMIC ACID COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS

This invention pertains generally to treating bacterial infections using organic compounds of Formula I. In certain aspects, the invention pertains to treating infections caused by Gram-negative bacteria. (I) wherein X, Y, R1, R2, R3, R4 and R5 and defined herein.

Practical synthesis of aryl-2-methyl-3-butyn-2-ols from aryl bromides via conventional and decarboxylative copper-free Sonogashira coupling reactions

Two efficient protocols for the palladium-catalyzed synthesis of aryl-2-methyl-3-butyn-2-ols from aryl bromides in the absence of copper were developed. A simple catalytic system consisting of Pd(OAc)2 and P(p-tol)3 using DBU as the base and THF as the solvent was found to be highly effective for the coupling reaction of 2-methyl-3-butyn-2-ol (4) with a wide range of aryl bromides in good to excellent yields. Analogously, the synthesis of aryl-2-methyl-3-butyn-2-ols was performed also through the decarboxylative coupling reaction of 4-hydroxy-4-methyl-2-pentynoic acid with aryl bromides, using a catalyst containing Pd(OAc)2 in combination with SPhos or XPhos in the presence of tetra-n-butylammonium fluoride (TBAF) as the base and THF as the solvent. Therefore, new efficient approaches to the synthesis of terminal acetylenes from widely available aryl bromides rather than expensive iodides and using 4 or propiolic acid rather than TMS-acetylene as inexpensive alkyne sources are described.

LITHIUM PEROXYACETYLENIDES IN THE SYNTHESIS OF PEROXYALKYNOIC ACIDS

A method was proposed for synthesizing 4-methyl-4-tert-alkyl(cycloalkyl, aralkyl)peroxy-2-pentynoic acids by metallation of appropriate monosubstituted peroxyalkynes with butyllithium followed by carboxylation of the initially formed lithium peroxyacetylenides with solid carbon dioxide.Cyclohexylammonium salts of the peroxyalkynoic acids synthesized were prepared.