506436-33-5Relevant academic research and scientific papers
The facile synthesis of N-aryl isoxazolones as DNA intercalators under solvent-free conditions using microwave irradiation
Ebrahimlo, Ali Reza Molla
, p. 104 - 107 (2012/07/16)
The reaction of chloroheterocycles with some isoxazolones under microwave irradiation and under solvent-free conditions to give the corresponding mono isoxazolinyl derivatives is reported. The main advantages of this method are: (i) elimination of the nitrogen gas (N2), (ii) solvent-free conditions, (iii) microwave irradiation, (iv) avoiding the use of silica gel for purification of the products, and (v) higher and shorter reaction times. These compounds have potential applications as DNA intercalators.
Rearrangements of 2-pyridyl-3-arylaminoisoxazol-5(2H)-ones to imidazo[1,2-a]pyridines under flash-vacuum-pyrolysis
Setamdideh, Davood,Khanahmadzadeh, Salah,Khorshidi, Nasrin
, p. 2884 - 2890 (2012/07/17)
2-Pyridyl-3-arylaminoisoxazol-5(2H)-ones, rearranged under flash-vacuum-pyrolysis (FVP) conditions accompanied by elimination of carbon dioxide to give imidazo[1,2-a]pyridines in high to excellent yields (85-95 %).
Synthesis of 2-(5-nitropyrid-2-yl)-3-(4-substitutedphenyl)aminoisoxazol- 5(2h)-ones and their rearrangements to imidazo[1,2-a]-pyridines and indoles with triethylamine
Khalafy,Setamdideh,Dilmaghani, K. Akbari
, p. 907 - 916 (2007/10/03)
3-(4-Substitutedphenyl)aminoisoxazol-5(2H)-ones, substituted on nitrogen with a nitropyridine group, react with triethylamine to give imidazo[1,2-a]pyridines and indoles. With 4-bromophenyl and 4-methylphenyl group substituents only imidazopyridines are f
2-Aryl-3-arylaminoisoxazol-5(2H)-ones as sources of indoles and imidazo[1,2-a]pyridines
Jeffery, David,Prager, Rolf H,Turner, David,Dreimanis, Monica
, p. 9965 - 9972 (2007/10/03)
2-Aryl-3-arylaminoisoxazol-5(2H)-ones undergo solvolysis to form 1,3-dipoles that undergo intramolecular cyclisation to form either imidazopyridines or indoles. The mode of cyclisation is controlled by the electronegativity of the aryl substituents.
