50671-40-4

Upstream product

• 108-24-7 acetic anhydride 
• 1572-10-7 3⁽⁵⁾-phenylpyrazol-5⁽³⁾-amine 
• 827-41-8 3-phenylpyrazol-5-amine 
• 614-16-4 Benzoylacetonitrile 
• 64-19-7 acetic acid 
• 93-89-0 benzoic acid ethyl ester 
• 75-36-5 acetyl chloride 

Downstream Products

• 101476-66-8 ethyl-(5-phenyl-2H-pyrazol-3-yl)-amine 
• 129760-95-8 5,10-Dihydro-4-ethyl-2-phenylpyrazolo<1,5-a><1,3>-7-cyclohexandiazepin-5,10-dione 
• 129760-94-7 5,10-Dihydro-4-ethyl-2-phenylpyrazolo<1,5-a><1,3>-7-cyclohexendiazepin-5,10-dione 
• 129760-93-6 4-Ethyl-5,6,7,8-tetrahydro-2-phenylpyrazolo<1,5-a><1,3>diazepin-5,8-dione 
• 129760-96-9 5,8-Dihydro-4-ethyl-2-phenylpyrazolo<1,5-a><1,3>-diazepin-5,8-dione 

Relevant academic research and scientific papers

METHODS OF TREATING OR PREVENTING A PROTEOPATHY

Methods for the treatment or prevention of a proteopathy are described herein.

Direct synthesis of pyrazoles from esters using tert-butoxide-assisted C-(C=O) coupling

This paper describes the direct synthesis of pyrazoles from esters that comprises two sequential reactions: tert-butoxide-assisted C-C(=O) coupling reaction to yield β-ketonitrile or α,β-alkynone intermediates, and condensation by hydrazine addition. The method reported allows for easy control of the regioselectivity and structure of substituents at N-1, C-3, C-4 and/or C-5 positions.