50712-44-2Relevant academic research and scientific papers
GLC determination of indoprofen in plasma
Smith,Humphrey,Escalona Castillo
, p. 132 - 134 (1977)
Implementation of human bioavailability studies with the analgesic indoprofen required a rapid, sensitive, and convenient assay in blood plasma. A procedure based on ether extraction of acidified plasma, derivatization with diazomethane, and GLC analysis using a 3% OV 1 column was sufficiently sensitive for measurement of plasma indoprofen concentrations in the 0.4-16 μg/ml range. An average recovery of 99.0 ± 7.6% (SD) was achieved when the pentanoic acid homolog was employed as an internal standard.
Isoindolinone Synthesis: Selective Dioxane-Mediated Aerobic Oxidation of Isoindolines
Thapa, Pawan,Corral, Esai,Sardar, Sinjinee,Pierce, Brad S.,Foss, Frank W.
, p. 1025 - 1034 (2019/01/24)
N-Alkyl and N-aryl-isoindolinones were prepared by a dioxane-mediated oxidation of isoindoline precursors. The transformation exhibits unique chemoselectivity for isoindonlines. A chiral tertiary (3°)-benzylic position was not racemized during oxidation, and methyl indoprofen was prepared by late stage oxidation. Mechanistic studies suggest a selective H atom transfer, which avoids many known oxidation (by-)products of isoindolinones.
Transition metal free intramolecular selective oxidative C(sp3)-N coupling: Synthesis of N-aryl-isoindolinones from 2-alkylbenzamides
Verma, Ajay,Patel, Saket,Meenakshi,Kumar, Amit,Yadav, Abhimanyu,Kumar, Shailesh,Jana, Sadhan,Sharma, Shubham,Prasad, Ch. Durga,Kumar, Sangit
supporting information, p. 1371 - 1374 (2015/02/18)
A synthetic method has been developed for the preparation of biologically important isoindolinones including indoprofen and DWP205190 drugs from 2-alkylbenzamide substrates by transition metal-free intramolecular selective oxidative coupling of C(sp3)-H and N-H bonds utilizing iodine, potassium carbonate and di-tert-butyl peroxide in acetonitrile at 110-140 °C.
Lactam coupling as a versatile route to indoprofen analogs
Barnes, Keith D.,Chen, Ping,Chang, Yingyan,Lewis, Robert M.,Manley, Christopher M.,Mayhew, Nicholas J.,Steffke, Stephen H.,Wang, Guixing,Wang, Yi,Yang, Yuh-Lin A.,Lippert, John W.
experimental part, p. 67 - 72 (2011/03/19)
A convergent synthesis of indoprofen via a Buchwald coupling approach is reported. Using this methodology, indoprofen and a set of analogs of indoprofen were readily prepared. Copyright
METHODS AND COMPOSITIONS TO TREAT MOTOR NEURON DISEASE
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Page/Page column 30, (2008/06/13)
The invention features compositions and methods for treating motor neuron diseases, such as spinal muscular atrophy and amyotrophic lateral sclerosis. The compositions and methods include derivatives of indoprofen.
Novel α-thio-alkanoic acid derivatives
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, (2008/06/13)
Novel α-thio-alkanoic acid derivatives and a process for their preparation. These novel compounds can be easily converted to useful medicines.
