50717-32-3

Upstream product

• 611-35-8 4-chloroquinoline 
• 6337-51-5 2-(4-chlorophenyl)-4-hydroxyquinoline 
• 106-39-8 bromochlorobenzene 
• 347335-62-0 4-chloro-1-formyl-2-(4-chloro)phenyl-2H-quinoline 
• 70254-44-3 2,4-dihydroxyquinoline 
• 99-91-2 para-chloroacetophenone 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 703-61-7 2,4-dichloroquinoline 
• 221910-02-7 3-(2-aminophenyl)-1-(4-chlorophenyl)prop-2-yn-1-one 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 103694-46-8 N¹-[2-(4-chloro-phenyl)-[4]quinolyl]-N⁴,N⁴-bis-(2-hydroxy-ethyl)-1-methyl-butanediyldiamine 
• 103509-57-5 N'-[2-(4-chloro-phenyl)-[4]quinolyl]-N,N-bis-(2-hydroxy-ethyl)-propanediyldiamine 
• 677735-65-8 2-(4-chlorophenyl)-4-(p-tolyl)quinoline 
• 1236-90-4 2-(4-chlorophenyl)-4-phenylquinoline 
• 678973-61-0 2-(4-chlorophenyl)-4-(4-methoxyphenyl)quinoline 
• 113455-32-6 N,N-bis-(2-chloro-ethyl)-N'-[2-(4-chloro-phenyl)-[4]quinolyl]-propanediyldiamine; dihydrochloride 

Relevant academic research and scientific papers

Domino [3+2] cycloaddition/annulation reactions of β-(2-aminophenyl)-α,β-ynones with nitrile oxides: Synthesis of isoxazolo[4,5-c]quinolines

β-(2-Aminophenyl)-α,β-ynones react with nitrile oxides by domino [3+2] cycloaddition/annulation reactions giving rise to isoxazolo[4,5-c]quinolines in satisfactory yields. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS

The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and nonneoplastic diseases.

Synthesis of 2,4-diarylquinolines: Nickel-catalysed ligand-free cross-couplings of 4-chloro-2-arylquinolines with arylmagnesium halides in 2-methyltetrahydrofuran

A ligand-free and room temperature protocol for the synthesis of 2,4-diarylquinolines is described. Treatment of 4-chloro-2-arylquinolines with arylmagnesium halides in the presence of a catalytic amount of nickel(II) chloride without ligands in 2-methylt

A novel one-pot oxidative deformylation of N-formyldihydroquinolines employing ferric chloride hexahydrate. Synthesis of 4-chloro-2-phenylquinolines and 4-chloro-2-(1,3-diphenyl-1H-pyrazol-4-yl)quinolines

(Chemical Equation Presented) A novel versatile one-pot oxidative deformylation approach has been developed to synthesize 4-chloro-2- phenylquinolines and 4-chloro-2-(1,3-diphenyl-1H-pyrazol-4-yl)quinolines from the corresponding N-formyldihydroquinolines

4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

Screening of the Roche compound library led to the identification of 4-aminoquinoline 4 as structurally novel NR1/2B subtype selective NMDA receptor antagonist. The SAR which was developed in this series resulted in the discovery of highly potent and in vivo active blockers.

The Vilsmeier cyclization of 2′-azido and 2′-aminochalcones - A mild one pot synthesis of 2-aryl-4-chloroquinoline and its N-formyl-1,2-dihydro derivatives

The Vilsmeier cyclization of 2′-aminochalcones provides a mild one pot synthesis of 2-aryl-4-chloro-N-formyl-1,2-dihydroquinolines. The scope of the reaction has been extended for the synthesis of quinolines themselves, by replacing 2′-aminochalcones with 2′-azidochalcones as the starting material. The yields are reasonably good and a plausible mechanism for the formation of the products in each case has been discussed.

4-Piperidino-2-phenylquinolines

Disclosed are compounds of the formula STR1 wherein: R1 and R2 may be either the same or different and each is hydrogen or lower alkyl; and wherein R3 and R4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R3 and R4 cannot both be hydrogen. These compounds are useful as anticonvulsant or anxiolytic agents.