50717-32-3

Basic information

• Product Name: Quinoline, 4-chloro-2-(4-chlorophenyl)-
• CAS NO: 50717-32-3
• Molecular Formula: C15H9Cl2N
• Molecular Weight: 274.149
• Mol File: 50717-32-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Quinoline, 4-chloro-2-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 4-chloro-2-(4-chlorophenyl)-(50717-32-3)
• EPA Substance Registry System: Quinoline, 4-chloro-2-(4-chlorophenyl)-(50717-32-3)

Safety Data

• Hazardous Substances Data: 50717-32-3(Hazardous Substances Data)

Upstream product

• 6337-51-5 2-(4-chlorophenyl)-4-hydroxyquinoline 
• 68-12-2 N,N-dimethyl-formamide 
• 611-35-8 4-chloroquinoline 
• 221910-02-7 3-(2-aminophenyl)-1-(4-chlorophenyl)prop-2-yn-1-one 
• 347335-62-0 4-chloro-1-formyl-2-(4-chloro)phenyl-2H-quinoline 
• 1679-18-1 4-Chlorophenylboronic acid 
• 703-61-7 2,4-dichloroquinoline 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 99-91-2 para-chloroacetophenone 
• 70254-44-3 2,4-dihydroxyquinoline 
• 106-39-8 bromochlorobenzene 

Downstream Products

• 103694-46-8 N¹-[2-(4-chloro-phenyl)-[4]quinolyl]-N⁴,N⁴-bis-(2-hydroxy-ethyl)-1-methyl-butanediyldiamine 
• 103509-57-5 N'-[2-(4-chloro-phenyl)-[4]quinolyl]-N,N-bis-(2-hydroxy-ethyl)-propanediyldiamine 
• 1236-90-4 2-(4-chlorophenyl)-4-phenylquinoline 
• 678973-61-0 2-(4-chlorophenyl)-4-(4-methoxyphenyl)quinoline 
• 677735-65-8 2-(4-chlorophenyl)-4-(p-tolyl)quinoline 
• 113455-32-6 N,N-bis-(2-chloro-ethyl)-N'-[2-(4-chloro-phenyl)-[4]quinolyl]-propanediyldiamine; dihydrochloride 

Relevant articles and documents

Domino [3+2] cycloaddition/annulation reactions of β-(2-aminophenyl)-α,β-ynones with nitrile oxides: Synthesis of isoxazolo[4,5-c]quinolines

β-(2-Aminophenyl)-α,β-ynones react with nitrile oxides by domino [3+2] cycloaddition/annulation reactions giving rise to isoxazolo[4,5-c]quinolines in satisfactory yields. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Synthesis of 2,4-diarylquinolines: Nickel-catalysed ligand-free cross-couplings of 4-chloro-2-arylquinolines with arylmagnesium halides in 2-methyltetrahydrofuran

A ligand-free and room temperature protocol for the synthesis of 2,4-diarylquinolines is described. Treatment of 4-chloro-2-arylquinolines with arylmagnesium halides in the presence of a catalytic amount of nickel(II) chloride without ligands in 2-methylt

4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

Screening of the Roche compound library led to the identification of 4-aminoquinoline 4 as structurally novel NR1/2B subtype selective NMDA receptor antagonist. The SAR which was developed in this series resulted in the discovery of highly potent and in vivo active blockers.