5078-07-9

Upstream product

• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 5078-06-8 6-acetoxy-2-methylbenzoxazole 
• 3163-07-3 4-nitroresorcinol 
• 108-24-7 acetic anhydride 
• 23997-80-0 2,4-dimethoxyacetophenone oxime 
• 850925-13-2 2',4'-Dihydroxyacetophenone oxime 
• 6134-79-8 1-(2,4-dihydroxy-phenyl)-ethanone oxime 
• 2735-04-8 2,4-Dimethoxyaniline 
• 859815-01-3 2,4-diacetoxy-1-diacetylamino-benzene 
• 698-31-7 4-nitroso-1,3-benzenediol 
• 34781-86-7 4-aminoresorcinol hydrochloride 
• 75-36-5 acetyl chloride 
• 127-19-5 N,N-dimethyl acetamide 
• 79-24-3 Nitroethane 

Downstream Products

• 5078-08-0 2-Methyl-6-ethoxy-benzoxazol 
• 227941-80-2 2-methyl-6-benzoyloxybenzoxazole 
• 71516-09-1 2-Acetylamino-5-benzoyloxy-phenol 
• 1036393-28-8 C₁₅H₁₉NO₄ 
• 1036393-08-4 C₂₅H₂₅NO₄ 
• 1036394-75-8 C₁₈H₁₈FNO₃ 
• 951235-21-5 2-(2-(4-dimethylaminophenyl)vinyl)-benzooxazol-6-ol 
• 536974-97-7 6-(benzyloxy)-2-(bromomethyl)benzoxazole 
• 536974-98-8 4-({[6-(benzyloxy)benzoxazol-2-yl]methyl}(4H-1,2,4-triazol-4-yl)amino)benzonitrile 
• 537677-66-0 4-{[(6-hydroxybenzoxazol-2-yl)methyl](4H-1,2,4-triazol-4-yl)amino}benzonitrile 
• 1252592-60-1 6-(benzyloxy)-2-methylbenzoxazole 
• 1429197-43-2 2-methyl-6-{[(7S,8aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydro-pyrrolo[1,2-a]pyrazin-7-yl]oxy}-1,3-benzoxazole 
• 312600-96-7 6-fluoro-2-methylbenzo[d]oxazole 
• 644968-88-7 4-(acetylamino)-3-{[(2S)-2-methyloxiran-2-yl]methoxy}phenyl benzoate 

Relevant academic research and scientific papers

A novel method for the synthesis of oxazolocoumarin derivatives

Anodic oxidation of 7-hydroxycoumarin derivatives 1a-f in anhyd acetonitrile-lithium perchlorate at constant potential between 1.70-1.80 V (vs. Ag/10-2 M Ag+) using an undivided cell and platinium gauze electrodes leads to the formation of the corresponding oxazolocoumarin derivatives 2 and/or 3 according to the position of the second OH group in the benzene ring of the coumarin derivatives 1e,f. The formation of these oxidation products is discussed.

Benzoxazole compound and application thereof

The invention belongs to the field of medical treatment, and particularly relates to a benzoxazole compound and application thereof, wherein the benzoxazole compound has a compound structure as represented by a formula (A), and the compound can be used fo

Multicatalytic Beckmann rearrangement of 2-hydroxylarylketone oxime: Switchable synthesis of benzo[d]oxazoles and N-(2-hydroxylaryl)amides

A switchable synthesis route is developed for benzo[d]oxazole derivatives and (2-hydroxylaryl)benzamide from 2-hydroxylbenzeneketoxime using organomolecules (BOP-Cl, and CNC) and Lewis acid cocatalyzed Beckmann rearrangement (BR) reaction. Further, this reaction is switched using different organocatalysts.

IRE-1α INHIBITORS

PROBLEM TO BE SOLVED: To provide compounds which directly inhibit inositol requiring enzyme 1 (IRE-1α activity) in vitro, prodrugs, and pharmaceutically acceptable salts thereof. SOLUTION: The present invention provides a compound represented by formula (A) [R3 and R4 are H or the like; Q5-Q8, together with the benzene ring to which they are attached, form a benzofused ring, where at least one of Q5-Q8 is a heteroatom selected from N, O, and S. COPYRIGHT: (C)2016,JPOandINPIT

Utility of Nitrogen Extrusion of Azido Complexes for the Synthesis of Nitriles, Benzoxazoles, and Benzisoxazoles

The utility of the nitrogen extrusion reaction of azido complexes, generated in situ from the corresponding aldehydes or ketones with TMSN3 in the presence of ZrCl4 or TfOH, has been described. These azido complexes could undergo three different pathways, depending on the substrates. First, azido methanolate complexes or imine diazonium ions could lead to benzisoxazole products via an intramolecular nucleophilic substitution. Second, imine diazonium ions could also undergo either the elimination of proton to provide nitrile products in good to excellent yields or an aryl migration, followed by an intramolecular nucleophilic addition, to give benzoxazole products in good yields.

One-pot synthesis of benzoxazoles via the metal-free ortho-C-H functionalization of phenols with nitroalkanes

PPA-activated nitroalkanes are employed in the design of a one-pot cascade transformation involving metal-free and oxidant-free direct ortho-C-H functionalization, followed by Beckman rearrangement and intramolecular cyclocondensation to produce benzoxazoles and benzobisoxazoles directly from easily available phenols.

Development of a multikilogram synthesis of a chiral epoxide precursor to a CCR1 antagonist. Use of in situ monitoring for informed optimisation via fragile intermediates

The optimisation and scale up of a manufacturing route to a key intermediate, acetic acid 4-acetylamino-3-(2-methyl-oxiranyl- methoxy)phenyl ester (2), utilising a SNAr coupling, the hydro- genation of a nitro moiety and the conversion of a chi

Efficient synthesis of 2-substituted benzoxazoles via Beckmann rearrangement of 2-hydroxyaryl ketoximes using diethyl chlorophosphate

An efficient method for synthesis of 2-substituted benzoxazoles has been developed using diethyl chlorophosphate. 2-Hydroxyaryl ketoximes are efficiently converted to benzoxazoles by heating in the presence of diethyl chlorophosphate via Beckmann rearrangement of ketoxime in excellent yields. This method avoids the use of strong acids, harsh conditions, and long reaction times. Georg Thieme Verlag Stuttgart.

CYANOISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF

The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline compounds of the invention have the following structure: Formula (I).

NOVEL TRICYCLIC SPIRODERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The invention provides compounds of formula (I) wherein m, R1, n, R2, q, p, X, Y, R3, R4, t and, R5 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.