50844-81-0

Usage

Uses

Used in Pharmaceutical Industry:
(2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its unique chemical structure allows it to be incorporated into a wide range of molecules, making it a valuable component in drug development.
Used in Chelating Agents:
(2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID is used as a chelating agent for various metals. Its ability to form salts with metals makes it useful in applications where metal ion sequestration is necessary, such as in water treatment or industrial processes.
Used in Neurodegenerative Disease Treatment:
(2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID is used as a potential treatment for neurodegenerative diseases. Its ability to modulate various biological pathways and target specific cellular processes makes it a promising candidate for the development of therapies to combat these conditions.
Used in Cancer Treatment:
(2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID is used as a potential treatment for various types of cancer. Its ability to target cancer cells and inhibit their growth and proliferation makes it a valuable compound in the development of cancer therapies.
Used in Immune System and Inflammation Research:
(2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID is used in research to better understand its role in the immune system and inflammation. Its potential to modulate immune responses and reduce inflammation makes it an important compound for studying these processes and developing new treatments.

Upstream product

• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 112-36-7 3,6,9-trioxaundecane 
• 56-40-6 glycine 
• 89-52-1 o-acetylamino-benzoic acid 
• 50844-82-1 methyl 2-(2-methyl-4-oxoquinazolin-3(4H)-yl)acetate 
• 1769-24-0 2-methyl-4-quinazolone 
• 118-92-3 anthranilic acid 

Downstream Products

• 106924-02-1 3-(5-phenyl-1,3,4-oxadiazol-2-ylmethyl)-2-methyl-4(3H)-quinazolinone 
• 106924-04-3 3-(5-p-tolyl-1,3,4-oxadiazol-2-ylmethyl)-2-methyl-4(3H)-quinazolinone 
• 106924-07-6 3-(5-benzyl-1,3,4-oxadiazol-2-ylmethyl)-2-methyl-4(3H)-quinazolinone 
• 106924-06-5 3-(5-(p-hydroxyphenyl)-1,3,4-oxadiazol-2-ylmethyl)-2-methyl-4(3H)-quinazolinone 
• 106924-05-4 3-(5-p-anisyl-1,3,4-oxadiazol-2-ylmethyl)-2-methyl-4(3H)-quinazolinone 
• 106924-03-2 3-(5-o-chlorophenyl-1,3,4-oxadiazol-2-ylmethyl)-2-methyl-4(3H)-quinazolinone 
• 106924-08-7 3-(5-p-chlorophenoxymethyl-1,3,4-oxadiazol-2-ylmethyl)-2-methyl-4(3H)-quinazolinone 
• 63265-69-0 2-(2-methyl-4-oxoquinazolin-3(4H)-yl)-N-phenylacetamide 
• 16353-15-4 2-methyl-4-oxoquinazoline-3-acetic acid hydrazide 
• 40889-43-8 ethyl 2-methyl-4-oxo-3,4-dihydroquinazoline-3-acetate 

Relevant academic research and scientific papers

Development of 2-(4-oxoquinazolin-3(4 H)-yl)acetamide derivatives as novel enoyl-acyl carrier protein reductase (InhA) inhibitors for the treatment of tuberculosis

InhA, the enoyl acyl carrier protein reductase of Mycobacterium tuberculosis (MTB) is an attractive target for developing novel anti-tubercular agents. Twenty eight 2-(4-oxoquinazolin-3(4H)-yl)acetamide derivatives were synthesized and evaluated for their in vitro MTB InhA inhibition. Compounds were further evaluated for their in vitro activity against drug sensitive and resistant MTB strains and cytotoxicity against RAW 264.7 cell line. Compounds were docked at the active site of InhA to understand their binding mode and differential scanning fluorimetry was performed to ascertain their protein interaction and stability.

Synthesis, antimalarial and antibacterial activities of 3-amino acid- and aryl amine-substituted 2-methyl- 3H-quinalzolin-4-ones

A new series of 2-methyl-3H-quinazolinones substituted at the third position with amino acids (2-5) and aryl amine (6, 7) was designed, synthesized, and analyzed by infrared, NMR, and mass spectral analysis. Further, the compounds were screened for their in vivo antimalarial activity using the rodent malaria parasite Plasmodium yoelii (N-67) with the Swiss mice model. The compounds were also tested for their antibacterial activity. Birkhaueser Boston 2009.

Synthesis and Biological Activity of 3-(5-Aryl-1,3,4-oxadiazol-2-ylmethyl)-2-methyl-4(3H)-quinazolinones

Fourteen 3-(5-aryl-1,3,4-oxadiazol-2-ylmethyl)-2-methyl-4(3H)-quinazolinones (IV) have been prepared by condensation of the respective 2-methyl-4-oxo-3-quinazolineacetic acid hydrazides with different aromatic carboxylic acids in the presence of phosphoro