50868-78-5

Upstream product

• 32833-96-8 N,N-dimethyloxamic acid 
• 588-16-9 m-methoxyacetanilide 
• 75-36-5 acetyl chloride 
• 4294-95-5 4-methoxyanthranilic acid 
• 50868-75-2 5’-methoxy-2’-methylacetanilide 
• 7487-88-9 magnesium sulfate 

Downstream Products

• 1110813-31-4 Dacomitinib 
• 1269400-04-5 N'-(2-cyano-5-methoxy-4-nitrophenyl)-N,N-dimethylmethanimidamide 
• 362512-37-6 2-hydrazino-4-methoxybenzoic acid 
• 4294-95-5 4-methoxyanthranilic acid 

Relevant academic research and scientific papers

Preparation method of Dactinib key intermediate

The invention provides a preparation method of a Dacomitinib key intermediate. The preparation method comprises the following steps: taking Dacomitinib as a raw material; the intermediate is short in synthetic route, mild in reaction condition, short in reaction time, simple in separation and purification method and low in cost, raw materials and reagents are all conventional reagents, and the prepared product is high in yield and quite beneficial to industrial production and popularization and has good application prospects.

Palladium-catalyzed C-H bond carboxylation of acetanilides: An efficient usage of N,N-dimethyloxamic acid as the carboxylate source

N,N-Dimethyloxamic acid can be successfully employed as a carboxylate precursor in the palladium-catalyzed direct C-H carboxylation of acetanilides. The reaction proceeds smoothly under mild conditions over a broad range of substrates with high functional group tolerance, affording substituted N-acyl anthranilic acids in moderate to high yields.