2-acetamido-4-methoxybenzoic acid

Base Information

• Chemical Name: 2-acetamido-4-methoxybenzoic acid
• CAS No.: 50868-78-5
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.202
• Mol file: 50868-78-5.mol

Synonyms:2-acetamido-4-methoxybenzoic acid

Chemical Property of 2-acetamido-4-methoxybenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-acetamido-4-methoxybenzoic acid

There total 6 articles about 2-acetamido-4-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

acetyl chloride (75-36-5) + 4-methoxyanthranilic acid (4294-95-5) → 2-acetamido-4-methoxybenzoic acid (50868-78-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 76.0%

N,N-dimethyloxamic acid (32833-96-8) + m-methoxyacetanilide (588-16-9) → 2-acetamido-4-methoxybenzoic acid (50868-78-5)

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 80 ℃; for 24h; Schlenk technique;

DOI:10.1039/c5cc07890c

Reference yield:

5’-methoxy-2’-methylacetanilide (50868-75-2) → 2-acetamido-4-methoxybenzoic acid (50868-78-5)

Guidance literature:

With water; permanganate(VII) ion; magnesium sulfate;

upstream raw materials:

5’-methoxy-2’-methylacetanilide

magnesium sulfate

N,N-dimethyloxamic acid

m-methoxyacetanilide

Downstream raw materials:

Dacomitinib

N'-(2-cyano-5-methoxy-4-nitrophenyl)-N,N-dimethylmethanimidamide

2-hydrazino-4-methoxybenzoic acid

4-methoxyanthranilic acid

Refernces

• 1、 Wu, Yinuo,Jiang, Cheng,Wu, Deyan,Gu, Qiong,Luo, Zhang-Yi,Luo, Hai-Bin. "Palladium-catalyzed C-H bond carboxylation of acetanilides: An efficient usage of N,N-dimethyloxamic acid as the carboxylate source". supporting information. p. 1286 - 1289. Retrieved 2016/01/15.