50892-81-4

Basic information

• Product Name: 1-(2-Furyl)-pyrido(3,4-b)indole
• Synonyms: 1-(2-Furyl)-pyrido(3,4-b)indole
• CAS NO: 50892-81-4
• Molecular Formula: C15H10 N2 O
• Molecular Weight: 234.25
• Mol File: 50892-81-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 468.7°Cat760mmHg
• Flash Point: 247.8°C
• Appearance: /
• Density: 1.321g/cm³
• Vapor Pressure: 1.65E-08mmHg at 25°C
• Refractive Index: 1.738
• CAS DataBase Reference: 1-(2-Furyl)-pyrido(3,4-b)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Furyl)-pyrido(3,4-b)indole(50892-81-4)
• EPA Substance Registry System: 1-(2-Furyl)-pyrido(3,4-b)indole(50892-81-4)

Safety Data

• Hazardous Substances Data: 50892-81-4(Hazardous Substances Data)

Usage

General Description

1-(2-Furyl)-pyrido(3,4-b)indole is a chemical compound that belongs to the family of polycyclic aromatic hydrocarbons (PAHs). It is commonly found in cigarette smoke and is classified as a Group 2B carcinogen, meaning it is possibly carcinogenic to humans. Studies have shown that exposure to this compound can lead to DNA damage and has been linked to an increased risk of respiratory tract and bladder cancer. Additionally, it has been identified in environmental pollution and occupational settings, highlighting the need for further research into its potential health effects and the implementation of measures to limit exposure.

InChI:InChI=1/C15H10N2O/c1-2-5-12-10(4-1)11-7-8-16-15(14(11)17-12)13-6-3-9-18-13/h1-9,17H

Upstream product

• 98-01-1 furfural 
• 73-22-3 L-Tryptophan 
• 54-12-6 Trp 
• 98-00-0 (2-furyl)methyl alcohol 
• 17119-54-9 DL-2-amino-2-(furan-2-yl)acetic acid 
• 61-54-1 tryptamine 
• 5912-10-7 N-(furan-2-ylmethylene)-2-(1H-indol-3-yl)ethanamine 
• 80360-20-9 1-(phenylsulfonyl)indole-3-carbaldehyde 
• 617-90-3 2-furancarbonitrile 
• 82980-12-9 3-ethenyl-1-phenylsulfonyl-1H-indole 
• 50-81-7 ascorbic acid 
• 50892-82-5 1-furan-2-yl-3,4-dihydro-β-carboline 
• 5912-11-8 1-(furan-2-yl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole 
• 58-86-6 D-xylose 

Downstream Products

• 29700-20-7 perlolyrine 

Relevant articles and documents

Studies on the Maillard reaction. VII. Formation of β carbolin derivatives by reaction of tryptamine with xylose and glucose

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Application of metal free aromatization to total synthesis of perlolyrin, flazin, eudistomin U and harmane

Application of our recently reported metal free reaction conditions to the total synthesis of the four different and selective biologically interesting β-carboline natural products is reported. Using this simple methodology, flazin, perlolyrine, eudistomin U and harmane containing heteroaryl and alkyl substituents at C1 position were synthesized in good yields. (Figure presented.).

Organic base-promoted efficient dehydrogenative/decarboxylative aromatization of tetrahydro-β-carbolines into β-carbolines under air

Organic base DBN has been identified as an efficient reagent for promoting the dehydrogenative/decarboxylative aromatization of tetrahydro-β-carbolines under air atmosphere, to access the corresponding β-carbolines in moderate to good yields. The utility of this protocol for the gram-scale synthesis of β-carboline alkaloids eudistomin U (7) and harmane (10) has also been demonstrated.