50971-75-0

Basic information

• Product Name: 3-(4-BENZHYDRYL-1-PIPERAZINYL)-1-PROPANAMINE
• Synonyms: 3-(4-BENZHYDRYL-1-PIPERAZINYL)-1-PROPANAMINE;3-[4-(diphenylmethyl)-1-piperazinyl]-1-propanamine
• CAS NO: 50971-75-0
• Molecular Formula: C₂₀H₂₇N₃
• Molecular Weight: 309.44848
• Mol File: 50971-75-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 436.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.072±0.06 g/cm3(Predicted)
• PKA: 10.39±0.10(Predicted)
• CAS DataBase Reference: 3-(4-BENZHYDRYL-1-PIPERAZINYL)-1-PROPANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-BENZHYDRYL-1-PIPERAZINYL)-1-PROPANAMINE(50971-75-0)
• EPA Substance Registry System: 3-(4-BENZHYDRYL-1-PIPERAZINYL)-1-PROPANAMINE(50971-75-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 50971-75-0(Hazardous Substances Data)

Usage

Classification

Piperazine derivative

Function

Psychoactive drug

Potential Treatments

Depression, anxiety, schizophrenia

Mechanism of Action

Serotonin receptor antagonist
Modulation of brain neurotransmitter levels

Abuse Potential

Known to produce psychoactive effects

Controlled Substance

Restricted in many countries

Further Research

Needed to fully understand benefits and risks

Upstream product

• 75591-22-9 1-(3-chloropropyl)-4-(diphenylmethyl)piperazine 
• 90096-39-2 1-benzhydryl-4-(3-hydroxypropyl)piperazine 
• 776-74-9 Bromodiphenylmethane 
• 841-77-0 diphenylmethylpiperazine 
• 542-76-7 3-Chloropropionitrile 
• 93358-79-3 2-[3-(4-benzhydryl-piperazin-1-yl)-propyl]-isoindole-1,3-dione 
• 50971-74-9 3-[4-diphenylmethyl-piperazin-1-yl]-propionitrile 

Downstream Products

• 274672-85-4 6-hydroxy-3-(3-(4-(diphenylmethyl)piperazinyl)propyl)-2-thioxohydroquinazoline-4-one 
• 274672-78-5 N-(3-(4-(diphenylmethyl)piperazinyl)propyl)(2-aminophenyl)formamide 

Relevant articles and documents

Hydrogenated acridine derivative and its application

The invention relates to the field of chemical synthesis, and particularly relates to a compound with the general formula being Y-L-X and an application of the compound serving as a calcium channel blocking agent or/and an acetylcholinesterase inhibitor. The compound with the general formula being Y-L-X can be used for adjusting calcium homeostasis and treating cardiovascular diseases, stroke or dementia.

Cyanoguanidine compounds

A cyanoguanidine compound of the following formula: is disclosed. A cyanoguanidine compound of the present invention possess a high specificity for tumor cells. Also disclosed are methods for preparing a cyanoguanidine compound.

Synthesis and histamine H1-receptor antagonist activity of 4-(diphenylmethyl)-1-piperazine derivatives with a terminal heteroaryl or cycloalkyl amide fragment

New 4-(diphenylmethyl)-1-piperazine derivatives with a terminal heteroaryl or cycloalkyl amide fragment were synthesized and evaluated for their antihistaminic anticholinergic and antiallergic activities. Tested compounds were found to be moderate to potent in vitro (guinea-pig ileum) histamine H1-receptor antagonists. Derivatives with a four methylene chain (1e-1h) were as potent in vivo (capillary permeability in rats) as cetirizine; the heteroaryl derivatives 1e and 1h were found to be the most active agents. These compounds displayed only weak in vitro (guinea-pig ileum) muscarinic M3-receptor antagonist activity. Compounds 1e and 1g were about 100 times more potent than ketotifen in preventing the compound 48/80-induced histamine release from rat peritoneal mast cells. Derivatives 1e, 1f and 1h did not modify the spontaneous motor activity in rats at 100 mg/kg po. Compound 1e has been selected for further studies.