50975-53-6Relevant academic research and scientific papers
Hypochlorite responsive even hydrazide connecting key and application thereof
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Paragraph 0091; 0094; 0096, (2019/01/13)
The invention discloses a hypochlorite responsive even hydrazide connecting key and application thereof. A structural formula of the connecting key is (with the reference to the specification); the connecting key is prepared from an R1 parent containing reactive carbonyl and an R2 parent containing reactive carbonyl by a reaction with hydrazine hydrate; the reactive carbonyl can be ester, carboxylic acid, acyl chloride, aldehyde or cyclic ketone. The connecting key can react with specificity of OCl, is oxidized and cut off by OCl to form carboxyl so as to distinguish OCl in ROS, has high specificity, and can be widely used in various fields of hypochlorite response, such as a hypochlorite fluorescent probe, a hypochlorite responsive drug carrier, a hypochlorite responsive nano probe, a prodrug for treating ROS related diseases, a carrier with double effects of diagnosis and treatment and the like.
Oxidation of Aroyl Hydrazines: Part X - Kinetics of Oxidation of Benzoyl Hydrazines by Chloramine-T in Alkaline Medium
Ramaiah, A. Kodanda,Rao, P. V. Krishna
, p. 1120 - 1122 (2007/10/02)
The kinetics of oxidation of benzoyl hydrazines by chloramine-T (CAT) in aq. methanol medium in the pH range 8.9-11.5 has been investigated.The order of reaction with respect to the oxidant and substrate is one each.The rate is found to be independent of pH.The reaction is accelerated by electron withdrawing groups and retarded by electron releasing groups, with a ρ value of + 0.80.An increase in the dielectric constant of the medium increases the rate whereas the ionic strength has no significant effect.A suitable mechanism has been suggested.
