51010-48-1Relevant academic research and scientific papers
Construction of C-C Bond via C-N and C-O Cleavage
He, Rong-De,Pang, Xiaobo,Shu, Xing-Zhong
, p. 635 - 640 (2020/04/07)
The construction of a C-C bond is a center subject in synthetic organic chemistry. The cross-electrophile coupling has provided a powerful tool to forge the C-C bond. However, this process generally requires organic halides, which has severely restricted
Benzylation of Arenes with Benzyl Halides under Promoter-Free and Additive-Free Conditions
Cheng, Xinqiang,Shan, Jiankai,Tian, Xinshe,Ren, Yun-Lai,Zhu, Yanyan
supporting information, p. 4404 - 4410 (2019/07/03)
It was found that benzyl chlorides and bromides could directly react with electron-rich arenes, which provided an example of promoter-free and additive-free benzylation of arenes. A variety of benzyl chlorides and bromides were treated with benzene rings to give the targeted products in low to high yields. The present conditions tolerated the vinyl group of the substrates. Preliminary mechanistic investigation suggests that the present reactions possibly proceed via an autocatalytic mechanism pathway.
Reductive Coupling between C-N and C-O Electrophiles
He, Rong-De,Li, Chun-Ling,Pan, Qiu-Quan,Guo, Peng,Liu, Xue-Yuan,Shu, Xing-Zhong
, p. 12481 - 12486 (2019/09/04)
The cross-electrophile reaction is a promising strategy for C-C bond formation. Recent studies have focused mainly on reactions with organic halides. Here we report a coupling reaction between C-N and C-O electrophiles that demonstrates the possibility of constructing a C-C bond via C-N and C-O cleavage. Several reactions between benzyl/aryl ammonium salts and vinyl/aryl C-O electrophiles have been studied. Preliminary mechanistic studies revealed that the benzyl ammoniums were activated through a radical mechanism.
Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.
Ahn, Jin Hee,Cho, Sung Yun,Ha, Jae Du,Chu, So Young,Jung, Sun Ho,Jung, Yoon Sung,Baek, Ji Yoen,Choi, In Kyung,Shin, Eun Young,Kang, Seung Kyu,Kim, Sung Soo,Cheon, Hyae Gyeong,Yang, Sung-Don,Choi, Joong-Kwon
, p. 1941 - 1946 (2007/10/03)
A new series of 1,2-naphthoquinone derivatives was synthesized by various synthetic methods and evaluated for their ability to inhibit protein tyrosine phosphatase 1B (PTP1B). 1,2-Naphthoquinone derivatives with substituent at R(4) position showed submicromolar inhibitory activity, and compound 24 demonstrated 10- to 60-fold selectivity against the tested phosphatases. Also, several 4-aryl-1,2-naphthoquinone derivatives with substituents at R(3), R(6), R(7), or/and R(8) showed submicromolar inhibitory activity and good plasma stability.
