51019-55-7Relevant academic research and scientific papers
Clicked AC regioisomer cationic cyclodextrins for enantioseparation
Zhou, Jie,Liu, Yun,Lu, Yingying,Tang, Jian,Tang, Weihua
, p. 54512 - 54516 (2015/02/05)
Novel AC regioisomer cationic cyclodextrins have been successfully prepared with azide/alkyne click chemistry. The clicked CDs were explored for the enantioseparation of acidic racemates in capillary electrophoresis.
Oxidative cleavage of α-aryl aldehydes using iodosylbenzene
Havare, Nizam,Plattner, Dietmar A.
, p. 5078 - 5081,4 (2020/09/15)
We found that α-aryl aldehydes can be cleaved to chain-shortened carbonyl compounds and formaldehyde by various iodosylbenzene complexes. A mechanistic scheme is presented that accounts for the loss of one carbon atom. Formaldehyde is further oxidized to CO and CO2 under the reaction conditions.
Iodide-catalyzed reductions: Development of a synthesis of phenylacetic acids
Milne, Jacqueline E.,Storz, Thomas,Colyer, John T.,Thiel, Oliver R.,Dilmeghani Seran, Mina,Larsen, Robert D.,Murry, Jerry A.
experimental part, p. 9519 - 9524 (2012/01/06)
A new convenient and scalable synthesis of phenylacetic acids has been developed via the iodide catalyzed reduction of mandelic acids. The procedure relies on in situ generation of hydroiodic acid from catalytic sodium iodide, employing phosphorus acid as the stoichiometric reductant.
Discovery of new C3aR ligands. Part 2: Amino-piperidine derivatives
Denonne, Frederic,Binet, Sophie,Burton, Maggi,Collart, Philippe,Defays, Sabine,Dipesa, Alan,Eckert, Maria,Giannaras, Alexander,Kumar, Seema,Levine, Beth,Nicolas, Jean-Marie,Pasau, Patrick,Pegurier, Cecile,Preda, Dorin,Van houtvin, Nathalie,Volosov, Andrew,Zou, Dong
, p. 3262 - 3265 (2008/02/08)
The synthesis and structure-activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are the first non-arginine ligands of C3aR.
Regioselective alkylation of lithium dienediolates of α,β- unsaturated carboxylic acids
Brun, Eva M.,Gil, Salvador,Mestres, Ramón,Parra, Margarita
, p. 1160 - 1165 (2007/10/03)
Lithium carboxylic acids dienediolates are regioselectively alkylated at the α-carbon by reaction with tosylates derived from both primary and secondary alcohols. Both regio- and diastereoselectivity are improved when compared with those obtained in the c
Oxidative decarboxylation of arylacetic acids mediated by peroxysulfur intermediate generated from 2-nitrobenzenesulfonyl chloride and superoxide
Kim II, Yong,Kim, Yong Hae
, p. 639 - 642 (2007/10/03)
The oxidative decarboxylation of aryl, α, α-diaryl, or arylalkylacetic acids has been achieved by a 2-nitrobenzenesulfonyl peroxy radical intermediate (I) generated by the reaction of 2-nitrobenzenesulfonyl chloride with potassium superoxide at -20°C in dry acetonitrile.
Deracemization of α-substituted arylacetic acids
Camps, Pelayo,Gimenez, Silvia
, p. 1227 - 1234 (2007/10/03)
Reaction of rac-α-substituted arylacetyl chlorides with (R)- and (S)-3-hydroxy-4,4-dimethyl-1-phenyl-2-pyrrolidinone under standard esterification conditions, gave esters (3R,αR)- and (3S,αS)-3, respectively, with a diastereoselectivity which diminishes on increasing the steric effect of the α-substituent. Controlled acidic hydrolysis of esters 3 afforded the corresponding acids 4 with minimal racemization. Boron tribromide demethylation of (R)- and (S)-4d gave without racemization the hydroxyacids (R)- and (S)-4e, known precursors of (R)- and (S)-iodoalphionic acid.
