510709-38-3

Upstream product

• 285-67-6 Cyclopentene oxide 

Downstream Products

• 89381-13-5 trans-2-hydroxycyclopentylamine 
• 18762-60-2 6-benzoyl-6-azabicyclo<3.1.0>hexane 
• 53226-42-9 N-cyclopentylbenzamide 
• 285-63-2 6-azabicyclo<3.1.0>hexane 

Relevant academic research and scientific papers

Lanthanide-based coordination polymers as promising heterogeneous catalysts for ring-opening reactions

This work presents the synthesis and structural characterization of Eu3+- and Tb3+-based coordination polymers starting from a Co3+-based metalloligand offering appended arylcarboxylic acid groups. Both coordination polymers function as reusable heterogeneous catalysts for ring-opening reactions utilizing amines, alcohols, thiols, and azides as the nucleophiles. The catalytic results illustrate an excellent control over the regioselectivity whereas a filtration test and mechanistic studies substantiate Lewis-acid catalyzed activation of the epoxide during the reaction.

Copper-catalyzed ring-opening reactions of alkyl aziridines with b2 pin2: Experimental and computational studies

The possibility to form new C–B bonds with aziridines using diboron derivatives con-tinues to be a particularly challenging field in view of the direct preparation of functionalized β-aminoboronates, which are important compounds in drug discovery, being a bioisostere of β-aminoacids. We now report experimental and computational data that allows the individua-tion of the structural requisites and of reaction conditions necessary to open alkyl aziridines using bis(pinacolate)diboron (B2 pin2 ) in a regioselective nucleophilic addition reaction under copper catalysis.

Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones

The esters of 1,2-azido alcohols were transformed into α-amido ketones without external oxidants through the Ru-catalyzed formation of N-H imines with the liberation of N2 followed by intramolecular migration of the acyl moiety. A wide range of α-amido ketones were obtained, and one-pot transformation into the corresponding oxazoles (or a thiazole) was demonstrated.

Modular, active, and robust lewis acid catalysts supported on a metal-organic framework

Metal-organic frameworks (MOFs) have shown promise as heterogeneous catalysts because of their high crystallinity, uniform pores, and ability to be chemically and physically tuned for specific chemical transformations. One of the challenges with MOF-based

Design and synthesis of a candidate α-human thrombin irreversible inhibitor containing a hydrophobic carborane pharmacophore

α-Human thrombin is a potent platelet agonist involved in the blood coagulation cascade and is an attractive target for an anticoagulant agent due to its involvement in several debilitating diseases. In this contribution we present attempts to develop a new architecture for size-selective serine protease inhibitors that utilize a fully methylated icosahedral p-carborane as a dominating hydrophobic pharmacophore. Using a computational docking program, flexX, a carborane-containing inhibitor was designed and synthesized. Computationally, this compound displayed the ability to provide ligand-protein binding interactions throughout the thrombin's main active site (S1-S3), while positioning an acylating group for facile irreversible attack at the Ser 195 hydroxyl group. Georg Thieme Verlag Stuttgart.

Asymmetric Catalysis by Vitamin B12: The Isomerization of Achiral Aziridines to Optically Active Allylic Amines

Achiral N-acylaziridines are isomerized to optically active N-acyl-allylamines in ee's of up to 95percent by catalytic amounts of cob(I)alamin in MeOH.