51116-93-9

Upstream product

• 51116-92-8 methyl 4,6-dimethoxysalicylate 
• 68-12-2 N,N-dimethyl-formamide 
• 557-21-1 dicyanozinc 
• 29723-28-2 methyl 2,4,6-trimethoxybenzoate 
• 4885-02-3 Dichloromethyl methyl ether 
• 83-30-7 acide 2,4,6-trihydroxybenzoique 

Downstream Products

• 89877-54-3 2-Hydroxy-4,6-dimethoxy-3-methyl-benzoesaeure-methylester 
• 5071-55-6 2-Hydroxy-3-hydroxymethyl-4,6-dimethoxy-benzoesaeure-methylester 
• 51116-94-0 C₂₁H₂₄O₁₀ 
• 773875-93-7 dimethyl 2-hydroxy-4,6-dimethoxy-1,3-benzenedicarboxylate 
• 869964-21-6 4,6-bis-tert-butyldimethylsilanyloxy-3-methyl-2-(2-oxoethyl)benzoic acid methyl ester 
• 1402589-17-6 4-(methoxycarbonyl)-6-methyl-5-(2-oxoethyl)-1,3-phenylene dibenzoate 
• 1402589-16-5 5-allyl-4-(methoxycarbonyl)-6-methyl-1,3-phenylene dibenzoate 
• 864514-39-6 methyl 2-allyl-4,6-dihydroxy-3-methylbenzoate 
• 67549-54-6 8-hydroxy-6-methoxy-3,5-dimethylisochroman-1-one 

Relevant academic research and scientific papers

Total Synthesis and Biological Evaluation of Irciniastatin A (a.k.a. Psymberin) and Irciniastatin B

Irciniastatin A (a.k.a. psymberin) and irciniastatin B are members of the pederin natural product family, which have potent antitumor activity and structural complexity. Herein, we describe a full account of our total synthesis of (+)-irciniastatin A and (-)-irciniastatin B. Our synthesis features the highly regioselective Eu(OTf)3-catalyzed, DTBMP-assisted epoxide ring opening reaction with MeOH, which enabled a concise synthesis of the C1-C6 fragment, extensive use of AZADO (2-azaadamantane N-oxyl) and its related nitroxyl radical/oxoammonium salt-catalyzed alcohol oxidation throughout the synthesis, and a late-stage assembly of C1-C6, C8-C16, and C17-C25 fragments. In addition, for the synthesis of (-)-irciniastatin B, we achieved the C11-selective control of the oxidation stage via regioselective deprotection and AZADO-catalyzed alcohol oxidation. The synthetic irciniastatins showed high levels of cytotoxic activity against mammalian cells. Furthermore, chemical footprinting experiments using synthetic compounds revealed that the binding site of irciniastatins is the E-site of the ribosome.

Synthesis of 8-desmethoxy psymberin: A putative biosynthetic intermediate towards the marine polyketide psymberin

The synthesis of a putative biosynthetic precursor of psymberin including a formal synthesis of the natural product is described. The key step towards the densely functionalized tetrahydropyran core was an enantioselective catalytic Mukaiyama aldol reacti

Studies on the total synthesis of lactonamycin: Synthesis of the CDEF ring system

A concise and efficient synthesis of the tetracyclic CDEF ring system of lactonamycin (1) is described. The key step involved the Lewis acid mediated, intramolecular Friedel-Crafts acylation of carboxylic acid 6 to produce the tetracyclic CDEF core struct

Trimethoxyphenyl Compounds, XI. Constituents of Hagenia abyssinica, 2: Synthesis of Phloracylophenones Containing One Phloroglucinol Unit

For the Koso constituents K6 and K8, we previously proposed the structures 1a, b and 2a, b.These assignments have been confirmed by synthesis. - Keywords: Flores koso, Revised Structure, Synthesis of Phloroglucinols