51163-40-7

Basic information

• Product Name: Pentanoic acid, 5-amino-5-oxo-4-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (S)-
• CAS NO: 51163-40-7
• Molecular Formula: C14H18N2O5
• Molecular Weight: 294.307
• Mol File: 51163-40-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Pentanoic acid, 5-amino-5-oxo-4-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 5-amino-5-oxo-4-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (S)-(51163-40-7)
• EPA Substance Registry System: Pentanoic acid, 5-amino-5-oxo-4-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (S)-(51163-40-7)

Safety Data

• Hazardous Substances Data: 51163-40-7(Hazardous Substances Data)

Upstream product

• 5672-80-0 N-Benzyloxycarbonyl-L-glutaminsaeure-5-methylester-1-(4-nitro-phenyl)-ester 
• 501-53-1 benzyl chloroformate 
• 1499-55-4 L-glutamic acid 5-methyl ester 
• 4124-76-9 N-(benzyloxycarbonyl)-L-glutamic acid anhydride 
• 821788-04-9 Carbobenzoxy-L-glutaminsaeure-1-thioethylester 
• 25126-07-2 N-(benzyloxycarbonyl)-L-glutamic acid, α-phenyl ester 
• 67-56-1 methanol 
• 6398-06-7 N-benzyloxycarbonyl-L-isoglutamine 
• 4652-65-7 (S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-methyl ester 
• 2650-64-8 Cbz-L-Gln 
• 208453-16-1 (S)-4-Benzyloxycarbonylamino-4-ethylsulfanylcarbonyl-butyric acid methyl ester 
• 186581-53-3 diazomethane 

Downstream Products

• 31883-92-8 (S)-methyl 4-{[(benzyloxy)carbonyl]amino}-4-cyanobutanoate 
• 636-65-7 glutamine 
• 56-85-9 L-glutamine 
• 96307-08-3 N-(benzyloxycarbonyl)-DL-(gln)Thz ethyl ester 
• 96391-81-0 N-Z-(R and S)(gln)Thz 
• 96307-07-2 N-(benzyloxycarbonyl)-L-γ-amino-γ-(thiocarbamoyl)butyramide 
• 31883-94-0 N-(benzyloxycarbonyl)-L-γ-amino-γ-cyanobutyric acid 
• 96307-06-1 N-(benzyloxycarbonyl)-L-γ-amino-γ-cyanobutyramide 
• 95716-10-2 Z-L-(glu)Thz-OH 

Relevant articles and documents

Constrained Cyclic β,γ-Diamino Acids from Glutamic Acid: Synthesis of Both Diastereomers and Unexpected Kinetic Resolution

We describe here an efficient synthesis of both diastereomers of cyclic β,γ-diamino acids starting from l-glutamic acid, based on the Blaise reaction. We show that by changing the protecting group, we can access either the five-membered-ring lactam, which

'BOP' as a reagent for mild and efficient preparation of esters

A simple procedure for preparation of esters under mild conditions employing the BOP reagent is reported. Acid and base labile protecting groups commonly used with amino acids e.g. t-butyl, Fmoc etc., are well tolerated under these conditions. The mechani

Synthesis of the Dolastatin Thiazole Amino Acid Component (gln)Thz

The new thiazole amino acid (gln)Thz, found to occur as one unit of the marine sea hare cyclic pentapeptide dolastin 3, has been synthesized from L-glutamic acid by the route 2 -> 10e.The synthesis of Z-L-isoglutamine (4) was improved by selective ammonolysis of anhydride 3 at -60 deg C.A variety of reaction conditions were found to cause complete racemization during the Hantzsch thiazole synthesis step (9 -> 10).Deuterium labeling experiments indicated loss of the chiral center prior to formation of the thiazole system and suggested an imine-enamine type equilibration involving intermediates A B (Scheme II).The N-benzyloxycarbonyl derivative (10d) of (gln)Thz was partially resolved by employing brucine.