512787-27-8

Basic information

• Product Name: 1-(pyrrolidin-1-yl)-2-p-tolylethanone
• Synonyms: 1-(pyrrolidin-1-yl)-2-p-tolylethanone;1-[(4-Methylphenyl)acetyl]pyrrolidine;2-(4-methylphenyl)-1-(pyrrolidin-1-yl)ethan-1-one
• CAS NO: 512787-27-8
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.28018
• Mol File: 512787-27-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(pyrrolidin-1-yl)-2-p-tolylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(pyrrolidin-1-yl)-2-p-tolylethanone(512787-27-8)
• EPA Substance Registry System: 1-(pyrrolidin-1-yl)-2-p-tolylethanone(512787-27-8)

Safety Data

• Hazardous Substances Data: 512787-27-8(Hazardous Substances Data)

Usage

General Description

1-(pyrrolidin-1-yl)-2-p-tolylethanone, also known as α-PVP or flakka, is a synthetic cathinone and psychoactive stimulant that is chemically related to pyrovalerone. It is a potent and highly addictive drug that acts as a norepinephrine-dopamine reuptake inhibitor, leading to increased levels of dopamine and norepinephrine in the brain. Users experience intense euphoria, heightened alertness, and increased energy, but also risk severe side effects such as paranoia, hallucinations, agitation, and violent behavior. The drug can also have harmful effects on the cardiovascular and nervous systems, and has been associated with numerous cases of overdose and death.α-PVP is classified as a Schedule I controlled substance in the United States, and its production, sale, and use are illegal in many other countries around the world.

Upstream product

• 123-75-1 pyrrolidine 
• 60512-56-3 1-(2,2-dibromovinyl)-4-methylbenzene 
• 104-87-0 4-methyl-benzaldehyde 
• 90892-09-4 bromoacetopyrrolidine 
• 15106-88-4 di(p-tolyl)zinc 
• 106-38-7 para-bromotoluene 
• 622-47-9 4-tolylacetic acid 

Downstream Products

• 622-47-9 4-tolylacetic acid 

Relevant articles and documents

Photoenzymatic Reductions Enabled by Direct Excitation of Flavin-Dependent "Ene"-Reductases

Non-natural photoenzymatic reactions reported to date have depended on the excitation of electron donor-acceptor complexes formed between substrates and cofactors within protein active sites to facilitate electron transfer. While this mechanism has unlocked new reactivity, it limits the types of substrates that can be involved in this area of catalysis. Here we demonstrate that direct excitation of flavin hydroquinone within "ene"-reductase active sites enables new substrates to participate in photoenzymatic reactions. We found that by using photoexcitation these enzymes gain the ability to reduce acrylamides through a single electron transfer mechanism.

Cobalt-Catalyzed α-Arylation of Substituted α-Bromo α-Fluoro β-Lactams with Diaryl Zinc Reagents: Generalization to Functionalized Bromo Derivatives

A cobalt-catalyzed cross-coupling of α-bromo α-fluoro β-lactams with diarylzinc or diallylzinc reagents is herein disclosed. The protocol proved to be general, chemoselective and operationally simple allowing the C4 functionalization of β-lactams. The substrate scope was expanded to α-bromo lactams and amides, α-bromo lactones and esters as well as N- and O-containing heterocycles.

An efficient method for one-carbon elongation of aryl aldehydes via their dibromoalkene derivatives

Various aryl aldehydes were efficiently converted into one-carbon extended aryl acetamides or aryl acetic acids through the reaction of their dibromoalkene derivatives with pyrrolidine in the presence of water under very mild conditions.