24299-77-2

Upstream product

• 67-56-1 methanol 
• 7663-76-5 3-(2-oxopyrrolidin-1-yl)propanenitrile 
• 616-45-5 2-pyrrolidinon 
• 292638-85-8 acrylic acid methyl ester 
• 51333-90-5 1-(2-chloro-ethyl)-pyrrolidin-2-one 
• 85839-16-3 4-(2-cyano-ethylamino)-butyric acid 

Downstream Products

• 77191-38-9 3-(2-oxopyrrolidin-1-yl)propionic acid 
• 77499-61-7 N-<2-(3,4-dimethoxyphenyl)ethyl>-3-(2-oxo-1-pyrrolidinyl)propionamide 
• 19748-66-4 3-pyrrolidin-1-yl-propan-1-ol 
• 47216-65-9 6,7-dimethoxy-1-<2-(2-oxo-1-pyrrolidinyl)ethyl>-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Synthesis, structure and reactivity of a macrocyclic imine: Aza-[13]-macrodiolides

The in situ synthesis and subsequent reactions of macrocylic imine 2 are reported. The imine was trapped with cyanotrimethylsilane to give α-amino nitrile aza-[13]-macrodiolides in a 1:1 ratio of diastereomers. A crystal structure of the syn α-cyano nitrile diastereomer, 7a, provided insights into the lack of selectivity in reactions of 2 relative to macrocyclic alkene 1. Reactions to functionalize the syn diastereomer 7a are also reported.

Synthesis, structure and reactivity of a macrocyclic imine: Aza-[13]-macrodiolides

The in situ synthesis and subsequent reactions of macrocylic imine 2 are reported. The imine was trapped with cyanotrimethylsilane to give α-amino nitrile aza-[13]-macrodiolides in a 1:1 ratio of diastereomers. A crystal structure of the syn α-cyano nitrile diastereomer, 7a, provided insights into the lack of selectivity in reactions of 2 relative to macrocyclic alkene 1. Reactions to functionalize the syn diastereomer 7a are also reported.

PHOTOCYCLISATION OF KETO-LACTAMS. A NEW SYNTHESIS OF FUNCTIONALIZED 1-AZA-BICYCLO(X.Y.0.)ALKANES

A series of 1-azabicyclo(x.y.0)alkanes has been synthesized using an intramolecular photoreduction.The methodology consists of a regioselective abstraction of a hydrogen α to the nitrogen of an amide by the triplet T1(n, ?*) of a carbonyl derivative.

Photo-oxidation of Oxazolidones and Hydantoins in the Presence of Benzophenone

Irradiation in the presence of benzophenone and oxygen of nitrogen-containing heterocycles having an NCO group yields products arising out of regioselective oxidation α to the nitrogen atom.Direct irradiation (in the absence of benzophenone and oxygen) of 5-methyl- and 5,5-dimethyl-hydantoins yields allophanates.The first step of this reaction involves the homolysis of the C(4) - C(5) bond of the hydantoin.