51463-66-2

Basic information

• Product Name: Phosphonic acid, (phenylacetyl)-, dimethyl ester
• CAS NO: 51463-66-2
• Molecular Formula: C10H13O4P
• Molecular Weight: 228.185
• Mol File: 51463-66-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, (phenylacetyl)-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, (phenylacetyl)-, dimethyl ester(51463-66-2)
• EPA Substance Registry System: Phosphonic acid, (phenylacetyl)-, dimethyl ester(51463-66-2)

Safety Data

• Hazardous Substances Data: 51463-66-2(Hazardous Substances Data)

Upstream product

• 103-80-0 phenylacetyl chloride 
• 121-45-9 phosphorous acid trimethyl ester 
• 103-82-2 phenylacetic acid 
• 96-36-6 methyl phosphite 

Downstream Products

• 67863-79-0 (5-benzyl-4-methoxy-3-methyl-2,4-dioxo-4λ⁵-[1,3,4]oxazaphospholidin-5-yl)-phosphonic acid dimethyl ester 
• 6876-65-9 N-(4-methylphenyl)-2-phenylacetamide 
• 67930-94-3 (5-benzyl-4-ethoxy-3-ethyl-2,4-dioxo-4λ⁵-[1,3,4]oxazaphospholidin-5-yl)-phosphonic acid dimethyl ester 
• 141543-05-7 (1-Hydroxy-1-nitromethyl-2-phenyl-ethyl)-phosphonic acid dimethyl ester 
• 868-85-9 Dimethyl phosphite 
• 937-39-3 2-phenylacetylhydrazine 
• 10264-08-1 N-cyclohexyl-2-phenyl-acetamide 
• 10264-09-2 N-butyl-2-phenylacetamide 
• 7500-45-0 N-benzylphenylacetamide 
• 1335122-52-5 dimethyl 1-(dimethylphosphoryloxy)-1-benzylmethylphosphonate 
• 1186436-73-6 C₁₃H₁₃N₂O₃P 
• 1186436-74-7 C₁₅H₁₈NO₅P 
• 705302-76-7 (E)-1-benzoyloxy-1-dimethoxyphosphoryl-2-phenylethene 

Relevant articles and documents

Multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters

The multiple-step, one-pot procedure for a series of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates, analogues of the natural, sulfur amino acid metabolite lanthionine ketimine (LK), its 5-ethyl ester (LKE) and 2-substituted LKEs is described. Initiating the synthesis with the Michaelis-Arbuzov preparation of α-ketophosphonates allows for a wide range of functional variation at the 2-position of the products. Nine new compounds were synthesized with overall yields range from 40 to 62%. In addition, the newly prepared 2-isopropyl-LK-P, 2-n-hexyl-LKE-P and 2-ethyl-LKE were shown to stimulate autophagy in cultured cells better than that of the parent compound, LKE.

Asymmetric hydrogenation of α- Or β-acyloxy α,β- unsaturated phosphonates catalyzed by a Rh(i) complex of monodentate phosphoramidite

The Rh(i) complex of a monodentate phosphoramidite bearing a primary amine moiety (DpenPhos) has been disclosed to be highly efficient for the asymmetric hydrogenation of a variety of α- or β-acyloxy α,β- unsaturated phosphonates, providing the corresponding biologically important chiral α- or β-hydroxy phosphonic acid derivatives with excellent enantioselectivities (90->99% ee).

Highly enantioselective synthesis of α-hydroxy phosphonic acid derivatives by Rh-catalyzed asymmetric hydrogenation with phosphine- phosphoramidite ligands

(Chemical Equation Presented) A class act: Unsymmetrical hybrid phosphine-phosphoramidite ligands with central and axial chirality are applied to the highly enantioselective hydrogenation of various enol ester phosphonates (see scheme; cod = cycloocta-1,5-diene). Enantioselectivities up to 99.9% ee are obtained for all classes of β-aryl, β-alkoxy, and β-alkyl substrates.