207994-08-9

Basic information

• Product Name: 5-chloro-3-fluoropyridine-2-carboxylic acid
• Synonyms: 5-chloro-3-fluoropyridine-2-carboxylic acid;5-chloro-3-fluoropicolinic acid;5-Chloro-3-fluoropicolinic acid, 2-Carboxy-5-chloro-3-fluoropyridine;2-Pyridinecarboxylic acid, 5-chloro-3-fluoro-;5-Chloro-3-fluoro-2-pyridinecarboxylic acid;5-Chloro-3-fluoro-pyridin-2-carboxylic acid
• CAS NO: 207994-08-9
• Molecular Formula: C₆H₃ClFNO₂
• Molecular Weight: 175.546
• Mol File: 207994-08-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 278.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.576±0.06 g/cm3(Predicted)
• PKA: 2.48±0.10(Predicted)
• CAS DataBase Reference: 5-chloro-3-fluoropyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-fluoropyridine-2-carboxylic acid(207994-08-9)
• EPA Substance Registry System: 5-chloro-3-fluoropyridine-2-carboxylic acid(207994-08-9)

Safety Data

• Hazardous Substances Data: 207994-08-9(Hazardous Substances Data)

Usage

General Description

5-Chloro-3-fluoropyridine-2-carboxylic acid is a chemical compound consisting of a pyridine ring with a carboxylic acid group and chlorine and fluorine substituents. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and functional groups make it an important building block in organic synthesis. The presence of both chlorine and fluorine atoms in its structure also imparts unique chemical properties, making it useful in a wide range of chemical reactions. The compound is also known for its potential biological activities, making it a subject of interest in medicinal chemistry research.

Upstream product

• 207994-06-7 3-fluoro-5-chloro-2-pyridinecarboxylic acid ethyl ester 
• 89402-43-7 5-chloro-2,3-difluoropyridine 
• 124-38-9 carbon dioxide 
• 514797-98-9 5-chloro-3-fluoro-2-iodopyridine 
• 514797-97-8 2-bromo-5-chloro-3-fluoro-pyridine 
• 514798-06-2 5-chloro-3-fluoro-2,4-diiodopyridine 
• 514798-05-1 2-bromo-5-chloro-3-fluoro-4-iodopyridine 
• 514797-96-7 5-chloro-3-fluoro-2(1H)-pyridinone 

Downstream Products

• 207994-09-0 3-fluoro-5-chloro-2-pyridinecarboxylic acid chloride 
• 1200498-40-3 methyl 5-chloro-3-fluoropicolinate 
• 1624603-44-6 N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-chloro-3-fluoropicolinamide 
• 1624605-33-9 N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-cyano-3-fluoropicolinamide 
• 1624605-32-8 N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-chloro-3-fluoropicolinamide 
• 1624605-04-4 N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-cyano-3-fluoropicolinamide 
• 1624606-67-2 N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-chloro-3-fluoropicolinamide 
• 1369542-91-5 (R)-N-{3-[6-amino-4-cyclopropyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl]-4-fluorophenyl}-5-chloro-3-fluoropyridine-2-carboxamide 
• 1352417-54-9 (2S,3R)-N-[3-(5-amino-3-cyclopropyl-2-fluoro-3,6-dihydro-2H-1,4-oxazin-3-yl)phenyl]-5-chloro-3-fluoropyridine-2-carboxamide 
• 1352417-55-0 (2R,3R)-N-[3-(5-amino-3-cyclopropyl-2-fluoro-3,6-dihydro-2H-1,4-oxazin-3-yl)phenyl]-5-chloro-3-fluoropyridine-2-carboxamide 
• 1600507-25-2 N-(3-((3R)-5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-6-chloroisoxazolo[4,5-b]pyridin-3-amine 
• 1600511-95-2 N-(5-(5-((6-chloroisoxazolo[4,5-b]pyridin-3-yl)amino)-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)benzamide 
• 1600535-78-1 (Z)-N-(5-(5-(5-chloro-3-fluoro-N'-hydroxypicolinimidamido)-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)benzamide 
• 214055-11-5 5-chloro-3-fluoropyridine-2-carbaldehyde 

Relevant articles and documents

Creating structural manifolds from a common precursor: Basicity gradient-driven isomerization of halopyridines

5-Chloro-2,3-difluoropyridine, an intermediate in the manufacturing process of an industrial pesticide, can be hydrolyzed to 5-chloro-3-fluoro-2H-pyridinone and the latter converted into 2,5-dichloro-3-fluoropyridine (1a), 2-bromo-5-chloro-3-fluoropyridine (1b), 5-chloro-3-fluoro-2-iodopyridine (1c) and 3-chloro-5-fluoropyridine (1d). Consecutive treatment of these four substrates with lithium diisopropylamide and carbon dioxide or lithium diisopropylamide and iodine affords the corresponding 4-pyridinecarboxylic acids 2 and 4-iodopyridines 3, respectively. Amide-promoted deprotonation of such 4-iodopyridines 3 triggers an isomerization in which lithium and iodine change places. The resulting species can be trapped with carbon dioxide to give the acids 5a-c or neutralized to give the halopyridines 4a-c. The iodopyridines 4a and 4b can be converted into the acids 6a and 6b, the latter product leading also to the congeners 6c and 6d. The diiodopyridine 4c provides an entry to the halopyridine 4d, which at the same time may act as the precursor to the acid 5d, the acid 7 or the bisacid 8. Finally, the acid 9 is accessible from either one of the 5-chloro-3-fluoro-2-halopyridines 1b and 1c. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).