18593-46-9

Upstream product

• 825-60-5 benzimidic acid ethyl ester 
• 4815-24-1 2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester 
• 100-47-0 benzonitrile 
• 63274-60-2 5,6-dimethyl-2-phenyl-4H-thieno[2,3-d][1,3]oxazin-4-one 
• 98-88-4 benzoyl chloride 
• 314284-10-1 2-benzamido-4,5-dimethylthiophene-3-carboxamide 
• 51486-04-5 2-amino-4,5-dimethylthiophene-3-carboxamide 
• 100-52-7 benzaldehyde 
• 2227-79-4 benzenecarbothioamide 
• 55502-96-0 2-amino-4,5-dimethylthiophene-3-carboxylate 

Downstream Products

• 401511-12-4 2-phenyl-4-[(2-hydroxy)ethyl]amino-5,6-dimethylthieno[2,3-d]pyrimidine 
• 1225504-90-4 5,6-dimethyl-2-phenyl-4-(prop-2-yn-1-yloxy)thieno[2,3-d]pyrimidine 
• 1225504-92-6 5,6-dimethyl-2-phenyl-3-prop-2-yn-1-ylthieno[2,3-d]pyrimidin-4(3H)-one 
• 1611471-56-7 5,6-dimethyl-4-morpholin-4-yl-2-phenylthieno[2,3-d]pyrimidine 
• 83548-67-8 (5,6-Dimethyl-2-phenyl-thieno[2,3-d]pyrimidin-4-yl)-hydrazine 
• 83548-75-8 8,9-Dimethyl-5-phenyl-tetrazolo[1,5-c]thieno[3,2-e]pyrimidine 

Relevant academic research and scientific papers

Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on the most active compounds. This journal is the Partner Organisations 2014.

Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H

The thienopyrimidinone 5,6-dimethyl-2-(4-nitrophenyl)thieno[2,3-d] pyrimidin-4(3H)-one (DNTP) occupies the interface between the p66 ribonuclease H (RNase H) domain and p51 thumb of human immunodeficiency virus reverse transcriptase (HIV RT), thereby indu

Synthesis and theoretical studies on energetics of novel N- and O- perfluoroalkyl triazole tagged thienopyrimidines - Their potential as adenosine receptor ligands

A series of novel N- and O- perfluoroalkyl triazole tagged thienopyrimidines 6a-c and 7a-d was synthesized in two steps from thienopyrimidin-4-ones 2 through O- and N-propargylated regioisomers 3a-i and 4a-i respectively. Compound 2 was reacted with propargyl bromide to form O- and N-propargylated regioisomers 3 and 4 in definite proportions. Each regioisomer was separated and independently subjected to [3?+?2] cycloaddition using perfluoroalkyl azides through Click reaction under Sharpless conditions and obtained exclusively anti product in each case. The formation of two regioisomers in the first step and single anti addition product in the next step could be explained based on computational studies carried out at B3LYP/6-31G(d) level of theory. Results of Fukui function indices at the reactive centers are in accordance with the observations. On evaluation of the synthesized molecules for their binding affinities towards adenosine receptors, 4d and 4f were found to be selective to A1 over A2A receptors.

Iodine catalysed synthesis and antibacterial evaluation of thieno-[2,3-d]pyrimidine derivatives

A new route via iodine catalysed heterocyclisation of 2-amino-4,5- dimethylthiophene-3-carboxamide with aromatic aldehydes affording a series of thieno[2,3-d]pyrimidine derivatives in a single step have been developed. Some of these compounds exhibited an

Synthesis of some new 2-arylthieno[2,3-d]pyrimidin-4(3H)-one derivatives

Some new derivatives of 2-arylthieno[2,3-d]pyrimidin-4(3H)-ones have been prepared through a condensation reaction of 2-amino-4,5-dimethylthiophene-3- carboxamide with aroyl halides in boiling pyridine followed by cyclisation with 10% NaOH.

Microwave-Assisted Synthesis of Novel 5-Substituted-2,3-dihydroimidazo[1,2-c]thieno[3,2-e]pyrimidines

A novel, facile microwave-assisted route for the synthesis of imidazo[1,2-c]thieno[3,2-e]pyrimidines 4 in quantitative yields is reported. The intermediates 4-chlorothieno[2,3-d]pyrimidines 3 were synthesized under one-pot reaction conditions.

Thienopyrimidin-4-(3H)ones

5,6-Dimethylthienopyrimidin-4(3H)-ones (V) have been synthesised by three new routes and their structures established by elemental analyses and PMR data.

Synthesis and Biological Activity of Tetrazolothienopyrimidines

4-Hydrazinothienopyrimidines (VI) undergo cyclization with nitrous acid to give tetrazolothienopyrimidines (VII).The latter compounds have been screened for their analgesic and antiinflammatory activities.