51491-78-2Relevant academic research and scientific papers
Facile construction of pyrrolo[1,2-: B] isoquinolin-10(5 H)-ones via a redox-amination-aromatization-Friedel-Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors
Wu, Shanchao,Liu, Na,Dong, Guoqiang,Ma, Lin,Wang, Shengzheng,Shi, Wencai,Fang, Kun,Chen, Shuqiang,Li, Jian,Zhang, Wannian,Sheng, Chunquan,Wang, Wei
, p. 9593 - 9596 (2016/08/01)
An efficient redox-amination-aromatization-Friedel-Crafts acylation cascade process from trans-4-hydroxyproline and 2-formylbenzoic acids has been developed for the synthesis of pyrrolo[1,2-b]isoquinolin-10(5H)-ones. Compound 3h was identified as a new potent dual topoisomerase I/II inhibitor.
An efficient entry to pyrrolo[1,2-b]isoquinolines and related systems through Parham cyclisation
Ruiz, Javier,Ardeo, Ainhoa,Ignacio, Roberto,Sotomayor, Nuria,Lete, Esther
, p. 3311 - 3324 (2007/10/03)
Aryllithiums generated by lithium-iodine exchange undergo intramolecular cyclisation to give pyrrolo[1,2-b]isoquinolines, in high yields. The best results were obtained when Weinreb or morpholine amides were used as internal electrophiles. The procedure h
Parham-type cycliacylation with Weinreb amides. Application to the synthesis of fused indolizinone systems
Ruiz, Javier,Sotomayor, Nuria,Lete, Esther
, p. 1115 - 1117 (2007/10/03)
(Matrix presented) Weinreb amides behave as efficient internal electrophiles in Parham-type cycliacylation reactions. Thus, aryl- and heteroaryllithiums generated by lithium-halogen exchange undergo intramolecular cyclization to give fused indolizinone systems as pyrrolo[1,2-b]isoquinolines, thieno[2,3-f]indolizinones, and pyrrolo[1,2-b]acridinones in high yields.
Metalation-cyclisation sequence on N-(o-halobenzyl)pyrroles. Synthesis of pyrrolo[1,2-b]isoquinolones
Ardeo, Ainhoa,Lete, Esther,Sotomayor, Nuria
, p. 5211 - 5214 (2007/10/03)
Parham-type cyclisation of N-(o-halobenzyl)pyrroles has been investigated. Aryllithiums generated from metalation of N-(o- iodobenzyl)pyrroles undergo intramolecular cyclisation to give pyrrolo[1,2- b]isoquinolinones in moderate to good yields, if the N,N
