51502-77-3

Upstream product

• 412309-23-0 (α-Cyanobenzylidene)-N,N-dimethyl-p-phenylenediamine 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 170300-50-2 4,4,4-Trifluoro-3-(p-chloroanilino)-2-phenyl-2-butenenitrile 
• 140-29-4 phenylacetonitrile 
• 18226-53-4 2-phenyl-3-(piperidin-1-yl)acrylonitrile 
• 18226-54-5 3-morpholin-4-yl-2-phenyl-acrylonitrile 
• 20265-96-7 p-chloroaniline hydrochloride 
• 2028-74-2 p-chlorobenzenediazonium chloride 

Relevant academic research and scientific papers

Enaminonitriles in heterocyclic synthesis: A route to 1,3-diaryl-4- Aminopyrazole derivatives

Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-Aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-Arylhydrazno-2-Arylethane nit

Heterocyclization of 2-aryl-3-arylamino-4,4,4-trifluoro-2-butenenitrile hydrates to 3-aryl-2-trifluoromethyl-4-quinolones and to 4-N-methylamino-3H-pyrazole-3-spiro-2'-(3'-aryl-3'-trifluoromethyl)axiranes

2-Aryl-3-arylamino-4,4,4-trifluoro-2-butenitriles were obtained as hydrates from 3-oxo-2-aryl-4,4,4-trifluorobutyronitriles and anilines and their structure and heterocyclizations studied.Cyclization with polyphosphoric acid gave poor yields of 3-aryl-2-trifluoromethyl-4-quinolones, but they underwent an interesting cyclization with diazomethane to give a 25percent-40percent yield of 4-N-methylamino-3H-pyrazole-3-spiro-2'-(3'-aryl-3'-trifluoromethyl)oxiranes.However, the related reaction with diazoethane yielded anly aryl(arylhydrazono)acetonitriles and other fragmentation products. - Keywords: Heterocyclizations; Fluorinated oxiranes; NMR spectroscopy; IR spectroscopy; UV spectrophotometry