51555-65-8Relevant articles and documents
1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB1 or CB2 receptor ligands
Piscitelli, Francesco,Ligresti, Alessia,La Regina, Giuseppe,Gatti, Valerio,Brizzi, Antonella,Pasquini, Serena,Allar, Marco,Carai, Mauro Antonio Maria,Novellino, Ettore,Colombo, Giancarlo,Di Marzo, Vincenzo,Corelli, Federico,Silvestri, Romano
experimental part, p. 5641 - 5653 (2012/01/02)
New 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides were synthesized as cannabinoid (CB) receptor ligands. Compound 11 (CB1 Ki = 2.3 nM, CB1 SI = 163.6) showed CB1 receptor affinity and selectivity superior to Rimonabant and AM251. Acute administration of 2 mg/kg 11 reduced sucrose, but not regular food, intake in rats. On the other hand, compound 23 (CB2 Ki = 0.51 nM, CB2 SI = 30.0) showed significant affinity and selectivity for the CB2 receptor. The results presented here show that the 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3- carboxamide may serve as an effective scaffold for the design of either CB 1 or CB2 receptor ligands.
1-phenylpyrroles
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, (2008/06/13)
Herbicidal 1-phenylpyrroles of the formula STR1 wherein each R1 represents methyl or together form a tetramethylene group, R2 represents hydrogen, C1-6 alkyl, cyclopropylmethyl, C1-4 alkoxy-C1-2 alkyl