51555-65-8

Upstream product

• 15753-50-1 cis-1,2-cyclohexanedimethanol 
• 79-37-8 oxalyl dichloride 
• 3971-29-7 1,2-bis(hydroxymethyl)cyclohexane 

Downstream Products

• 51649-35-5 4,5,6,7-tetrahydro-2H-isoindole 
• 1345992-78-0 1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydro-2H-isoindol-2-yl)-1H-pyrazole-3-carboxylic acid 
• 1345992-43-9 N-(3,4-dichlorobenzyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide 
• 1345992-44-0 N-cyclohexyl-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide 
• 145072-02-2 2-[(2R,3R)-3-((S)-1-Benzyloxy-ethyl)-2-methyl-pent-4-ynoylamino]-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylic acid methyl ester 
• 145072-06-6 2-[(3R,4R)-3-((S)-1-Benzyloxy-ethyl)-4-methyl-2-methylene-5-oxo-pyrrolidin-1-yl]-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylic acid methyl ester 
• 122181-86-6 1-carbomethoxy-2-amino-4,5,6,7-tetrahydro-2H-isoindole 
• 1345992-68-8 ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydro-2H-isoindol-2-yl)-1H-pyrazole-3-carboxylate 

Relevant academic research and scientific papers

1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB1 or CB2 receptor ligands

New 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides were synthesized as cannabinoid (CB) receptor ligands. Compound 11 (CB1 Ki = 2.3 nM, CB1 SI = 163.6) showed CB1 receptor affinity and selectivity superior to Rimonabant and AM251. Acute administration of 2 mg/kg 11 reduced sucrose, but not regular food, intake in rats. On the other hand, compound 23 (CB2 Ki = 0.51 nM, CB2 SI = 30.0) showed significant affinity and selectivity for the CB2 receptor. The results presented here show that the 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3- carboxamide may serve as an effective scaffold for the design of either CB 1 or CB2 receptor ligands.

Studies on the Synthesis of Phytochrome and Related Tetrapyrroles. Dihydropyrromethenones by Photochemical Rearrangement of N-Pyrrolo Enamides

Dihydropyrromethenone 67b, a potential precursor for the synthesis of phytochrome 1, has been prepared in enantiomerically pure form beginning with N-aminopyrrole 64 and the acetylenic acid 62b. The key step involved a 3,5-sigmatropic rearrangement of N-pyrrolo enamide 66b.

1-phenylpyrroles

Herbicidal 1-phenylpyrroles of the formula STR1 wherein each R1 represents methyl or together form a tetramethylene group, R2 represents hydrogen, C1-6 alkyl, cyclopropylmethyl, C1-4 alkoxy-C1-2 alkyl