51649-35-5

Usage

Uses

Used in Pharmaceutical Industry:
2H-Isoindole,4,5,6,7-tetrahydro-(9CI) is used as an intermediate in the synthesis of various pharmaceutical compounds for its unique structure and reactivity. It plays a crucial role in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2H-Isoindole,4,5,6,7-tetrahydro-(9CI) is utilized as a key component in the production of agrochemicals. Its incorporation aids in the development of effective and innovative products for agricultural applications, enhancing crop protection and yield.
Used in Organic Synthesis:
2H-Isoindole,4,5,6,7-tetrahydro-(9CI) serves as a versatile building block in organic synthesis, enabling the creation of a wide range of organic compounds. Its unique structure and reactivity make it an essential component in the synthesis of complex organic molecules, contributing to the advancement of organic chemistry.
Used in Research and Development:
2H-Isoindole,4,5,6,7-tetrahydro-(9CI) is also used as a subject of research for its potential biological activities. Scientists are exploring its properties and applications in various fields, including drug discovery and development, with the aim of uncovering new therapeutic agents and expanding the understanding of its biological potential.

Upstream product

• 65880-17-3 ethyl 4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate 
• 2562-37-0 1-nitrocyclohexene 
• 122181-89-9 2-((5'-carbomethoxy-4'-pentynoyl)amino)-4,5,6,7-tetrahydro-2H-isoindole 
• 110-83-8 cyclohexene 
• 823-45-0 2-(hydroxymethylene)cyclohexanone 
• 108-94-1 cyclohexanone 
• 122181-81-1 2-phthalimido-4,5,6,7-tetrahydro-2H-isoindole 
• 122181-82-2 2-amino-4,5,6,7-tetrahydro-2H-isoindole 
• 51555-65-8 cyclohexane-1,2-dicarbaldehyde 
• 930-68-7 cyclohexenone 
• 14032-03-2 1-chloro-2-phenylsulfanylcyclohexane 
• 931-59-9 benzenesulfenyl chloride 
• 33995-48-1 trans-2-chlorocyclohexyl phenyl sulfone 
• 14032-03-2 ((1R,2R)-2-chlorocyclohexyl)(phenyl)sulfane 

Downstream Products

• 865479-43-2 5,5-difluoro-3,7-dimethyl-10-phenyl-5H-4λ⁴,5λ⁴-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine 
• 1613627-43-2 C₁₅H₁₄N₂ 
• 1426521-09-6 C₁₅H₁₈N₂ 
• 1287673-74-8 (5,10,15-triphenyl-2:3,7:8,12:13,17:18-tetrabutanocorrolato)copper 

Relevant academic research and scientific papers

Porphyrins with Exocyclic Rings. Part 8 [1], Synthesis of Nitrogen-15 and Carbon-13 Labeled 2,3:7,8:12,13:17,18-Tetrabutanoporphyrin [2,3]

Nitrogen-15 labeled butyl 4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate was prepared via butyl isocyanoacetate from 15N-glycine in an overall 46% yield, This bicyclic intermediate was converted into nitrogen-15 and carbon-13 labeled 2,3:7,8:12, 13:17, 18-tetrabutanoporphyrin, a useful model system for the sedimentary tetrahydrobenzoporphyrins.

Highly non-planar dendritic porphyrin for pH sensing: Observation of porphyrin monocation

Metal-free porphyrin-dendrimers provide a convenient platform for the construction of membrane-impermeable ratiometric probes for pH measurements in compartmentalized biological systems. In all previously reported molecules, electrostatic stabilization (s

Benzoporphyrins: Selective Co-sensitization in Dye-Sensitized Solar Cells

A novel class of dyes, namely benzoporphyrins, was synthesized and implemented into dye-sensitized solar cells. They feature complementary absorptions compared to N719, which renders them promising candidates for co-sensitization in DSSCs. Notably, metallated benzoporphyrins reveal a TiO2-nanoparticle attachment that is size and aggregation dependent. Therefore, unproductive energy-transfer events between the selectively attached dyes can be prevented. In light of the latter, an efficiency improvement of 39 % has been achieved upon selective adsorption of benzoporphyrins and N719 onto different layers of TiO2 photoelectrode.

TAMBJAMINES AND B-RING FUNCTIONALIZED PRODIGININES

Embodiments of tambjamines and B-ring functionalized prodiginines are disclosed. Methods of synthesizing and using the disclosed compounds are also disclosed. Some embodiments of the disclosed compounds have antimalarial activity. Certain embodiments of t

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials

Synthesis and antimalarial activity of 94 novel bipyrrole tambjamines (TAs) and a library of B-ring functionalized tripyrrole prodiginines (PGs) against a panel of Plasmodium falciparum strains are described. The activity and structure-activity relationsh

Electrochemistry of nonplanar copper(II) tetrabutano- and tetrabenzotetraarylporphyrins in nonaqueous media

Two series of copper tetraarylporphyrins containing β,β′-fused tetrabutano or tetrabenzo groups were synthesized and characterized as to their electrochemistry and spectroelectrochemistry in nonaqueous media. The examined compounds are represented as butano-(TpYPP)CuII and benzo-(TpYPP)CuII, where TpYPP is the porphyrin dianion and Y is a CH3, H or Cl substituent on the para-position of the four meso-phenyl rings of the compound. Each neutral porphyrin in the two series is ESR active and shows a typical d9 Cu(ii) signal in frozen CH2Cl2 solution. Each Cu(ii) porphyrin also undergoes two reversible one-electron reductions and two reversible one-electron oxidations in DMF or CH2Cl2 containing 0.1 M tetra-n-butylammonium perchlorate to give a π-anion radical and dianion upon reduction and a π-cation radical and dication upon oxidation. A third one-electron oxidation is also observed for butano-(TpYPP)Cu (Y = CH3 and H) and benzo-(TPP)Cu in PhCN and this process is assigned to the CuII/CuIII transition. The reversible half-wave potential for the first oxidation of each compound in both series is shifted negatively by about 500 mV as compared to E1/2 values for oxidation of the related copper tetraarylporphyrin without the four fused benzo or butano rings while smaller positive shifts of 60 and 300 mV are seen for reduction of the tetrabenzotetraarylporphyrins and tetrabutaotetraarylporphyrins, respectively, as compared to the same redox reactions of the related tetraarylporphyrins. The electrochemically measured HOMO-LUMO gap averages 1.76 ± 0.05 V for benzo-(TpYPP)CuII, 2.04 ± 0.06 V for butano-(TpYPP)CuII and 2.33 ± 0.03 for (TpYPP)Cu in CH2Cl2.

OXYGEN SENSORS

Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.

Tunable phosphorescent NIR oxygen indicators based on mixed benzo-and naphthoporphyrin complexes

A series of π-extended phosphorescent palladium(II) and platinum(II) porphyrin complexes were synthesized, in which additional benzene rings are fused radially onto at least one of the four peripheral benzo groups. The photophysical properties of the metalloporphyrins palladium(II)-meso-tetra-(4- fluorophenyl)mononaphthotribenzoporphyrin (Pd1NF), cispalladium(II)-meso-tetra- (4-fluorophenyl)dibenzodinaphthoporphyrin (Pd2NF), and palladium(II)-meso-tetra- (4-fluorophenyl)monobenzotrinaphthoporphyrin (Pd3NF) and the corresponding platinum(II) compounds (Pt1NF, cis-Pt2NF, Pt3NF) were investigated. The compounds under investigation absorb intensively in the near-infrared region (628-691 nm) and emit at room temperature at 815-882 nm. Phosphorescence quantum yields of the platinum(II) porphyrins range from 25 to 53% with luminescence decay times of 21 to 44 μs in deoxygenated toluene solutions at room temperature. The corresponding palladium(II) complexes exhibit quantum yields in the range of 7 to 18% with lifetimes of 106 to 206 μs. Density functional theory (DFT) calculations revealed nonplanar geometries for all complexes and corroborate the absorption characteristics. The subsequent π extension of the porphyrin system leads to near-infrared absorbing oxygen indicators with tailor-made luminescence properties as well as tunable oxygen sensitivity.

Highly efficient, near-infrared electrophosphorescence from a Pt-metalloporphyrin complex

(Graph Presented) Red-shifting beyond red: The nonplanar porphyrin complex [Pt(tpbp)] (tpbp = tetraphenyltetrabenzoporphyrin) has been used as a phosphorescent dopant in highly efficient electrophosphorescent devices that emit in the near-infrared region