515824-21-2Relevant academic research and scientific papers
Highly-luminescent DTTA-appended lanthanide complexes of 4-(multi)fluoroaryl-2,2′-bipyridines: Synthesis and photophysical studies
Charushin, Valery N.,Chupakhin, Oleg N.,Egorov, Ilya N.,Kim, Grigory A.,Kopchuk, Dmitry S.,Krinochkin, Alexey P.,Nosova, Emiliya V.,Santra, Sougata,Shevyrin, Vadim A.,Zyryanov, Grigory V.
, (2020/12/25)
A number of new water-soluble 2,2′-bipyrdine Eu(III) and Tb(III) complexes have been prepared. The complexes are based on 4-(multi)fluoroaryl-2,2′-bipyridines bearing diethylenetriaminetetraacetic acid (DTTA) residue at C6 position. The study of their photophysical properties demonstrated the advantages of introducing fluorine atoms into the ligands. Strong lanthanide cation luminescence was observed, an increase in the quantum yield was especially noticeable for fluorine-containing Tb(III) complexes. An increase in solubility was also observed in comparison with some previously described complexes, including bromine- or chlorine-containing ones, whereas values of the Ln(III) cation luminescence quantum yields were found to be comparable.
Iridium/f-Amphox-Catalyzed Asymmetric Hydrogenation of Styrylglyoxylamides
Wang, Simin,Yu, Yuena,Wen, Jialin,Zhang, Xumu
supporting information, p. 2203 - 2207 (2018/09/29)
We report an iridium-catalyzed asymmetric hydrogenation reaction for the preparation of chiral homophenylalanine derivatives. Catalyzed by an iridium/f-amphox complex, the asymmetric hydrogenation of styrylglyoxylamides was conducted smoothly with turnover numbers of up to 10,000 and up to 98% ee. This method was successfully applied in a synthesis of a fragment of benazepril, a drug used for the treatment of high blood pressure.
A simple, diversity oriented synthesis of highly substituted pyridines
Kaczanowska, Katarzyna,Eickhoff, Holger,Albert, Klaus,Wiesmueller, Karl-Heinz,Schaffner, Arnaud-Pierre
experimental part, p. 792 - 798 (2011/09/16)
Figure represented. A particularly straightforward and efficient protocol for the synthesis of highly substituted pyridines, based on a condensation reaction of β-aminocrotonitrile and easily accessible (E)-2-oxo-4-aryl-but- 3-enoic acids and (E)-4-oxo-4-
Highly enantioselective intermolecular stetter reactions of β-aryl acceptors: α-ketoester moiety as handle for activation and synthetic manipulations
Sanchez-Larios, Eduardo,Thai, Karen,Bilodeau, Francois,Gravel, Michel
supporting information; experimental part, p. 4942 - 4945 (2011/11/29)
The use of β,γ-unsaturated-α-ketoesters in the intermolecular Stetter reaction furnishes 1,2,5-tricarbonyl compounds in high yield and excellent enantioselectivity. The α,δ-diketoesters generated using this methodology serve as useful synthetic building b
Direct asymmetric hydrogenation of 2-oxo-4-arylbut-3-enoic acids
Zhu, Lvfeng,Meng, Qinghua,Fan, Weizheng,Xie, Xiaomin,Zhang, Zhaoguo
supporting information; experimental part, p. 6027 - 6030 (2010/11/18)
A challenging direct asymmetric hydrogenation of (E)-2-oxo-4-arylbut-3- enoic acids to give 2-hydroxy-4-arylbutanoic acids (85.4-91.8% ee) was achieved with a Ru catalyst based on SunPhos as the chiral ligand. Further investigation of the reaction revealed that partial isomerization of 2-hydroxy-4-arylbutenoic acids was involved in the hydrogenation process. Employing the reaction conditions to the hydrogenation of 2-oxo-4-phenylbutanoic acid resulted in better enantioselectivity (91.8% ee) and efficiency (TON = 2000, TOF = 200 h-1), which offers a useful method for the synthesis of a common intermediate for ACE inhibitors.
The putative Diels-Alderase macrophomate synthase is an efficient aldolase
Serafimov, Joerg M.,Gillingham, Dennis,Kuster, Simon,Hilvert, Donald
supporting information; experimental part, p. 7798 - 7799 (2009/02/01)
We find that the putative Diels-Alderase macrophomate synthase (MPS) catalyzes the addition of pyruvate enolate, generated by decarboxylation of oxaloacetate, to a variety of aldehydes. Alkyl, aryl, and heteroaryl aldehydes are accepted as substrates, providing γ-hydroxy-α-ketoacids in 35-95% yield with modest levels of stereochemical control. These aldol products, which are difficult to synthesize by other methods, are formed with efficiency comparable to that of macrophomate. Our results thus provide evidence that a two-step Michael-aldol pathway is a plausible alternative to the postulated [4 + 2] cycloaddition in the MPS-catalyzed addition of pyruvate enolate to 2-pyrones. They are also relevant to understanding the divergent evolution of type II pyruvate aldolases. Copyright
