515875-68-0Relevant academic research and scientific papers
Synthesis of pyrimidines, thienopyrimidines and pyrazolopyrimidine
Kamal El-Dean, Adel M.,Abdel-Moneam, Maisa E.
, p. 1057 - 1060 (2007/10/03)
5-Ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6(1H)-thione (3), which was prepared from the reaction of ethyl β-aminocrotonate 1 with benzoyl isothiocyanate (2) in refluxing acetone, was reacted with halo compounds to give S-alkyl derivatives 4a-h. Treatment of compounds 4a-c with sod. ethoxide cyclized into thienopyrimidine 10a-c. Hydrazinolysis of compound 3 gave hydroxypyrazolopyrimidine derivative 6. Also the latter compound was obtained upon heating compound 4a with hydrazine hydrate under neat conditions, but when compound 4a refluxed with hydrazine hydrate in ethanol the corresponding carbohydrazide 5 was produced.
Synthesis of pyrimidines, thienopyrimidines, and pyrazolopyrimidines
Kamal El-Dean, Adel M.,Abdel-Moneam, Maisa E.
, p. 2745 - 2751 (2007/10/03)
5-Ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6(1H)-thione (3), which was prepared from the reaction of ethyl β-aminocrotonate 1 with benzoyl isothiocyanate (2) in refluxing acetone, was reacted with a series of halopgenated reagents to give S-alkyl derivatives 4a-g. Upon treatment of compounds 4a-c with sodium ethoxide were cyclized into thienopyrimidine 10a-c. Pyrimidinethione 3 was reacted with hydrazine hydrate to give hydroxypyrazolopyrimidine derivative 6. The later compound was obtained by heating compound 4a with hydrazine hydrate under neat conditions, but when the reaction was carried using hydrazine hydrate in ethanol, the corresponding carbohydrazide 5 was produced.
