5160-25-8

Upstream product

• 52389-41-0 1(3),3(1),4(6),5,6(4)-penta-O-acetyl-sn-myoinositol 
• 124-63-0 methanesulfonyl chloride 
• 87-89-8 D-myo-inositol 
• 13462-79-8 1⁽³⁾,4⁽⁶⁾,5,6⁽⁴⁾-tetra-O-acetyl-sn-myo-inositol 
• 6763-47-9 rac-1,2-O-cyclohexylidene-myo-inositol 
• 39110-61-7 3,4,5,6-tetra-O-acetyl-1,2-O-cyclohexylidene-myo-inositol 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF ALZHEIMER'S DISEASE AND RELATED DISORDERS

One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyIoidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.

Novel Discotic Liquid Crystalline, Polar Monothioscyllitol Derivatives

On the basis of an improved synthesis of the 1,3,4,5,6-pentaacetate of myo-inositol, now available in only one step from that cyclitol in yields up to 90percent, we prepared various derivatives 3-5 of 1-deoxy-1-mercapto-scyllo-inositol (monothioscyllitol) via the mesylate 1a or the trifluoromesylate 1b, respectively.The non-centrosymmetric disc-shaped thioethers 3a-h as well as their S,S-dioxides 4a-h and the S-oxide 5f exhibit thermotropic discotic mesophases over wide temperature ranges.The thermomesomorphism of these new sulfur compounds has been studied by optical microscopy and by differential scanning calorimetry.The pentabutyrates 3a and 4a as well as the dimesomorphic pentapentanoate 3b exhibit a probably new type of discophase Dx whereas all other monothioscyllitol derivatives with longer alkyl chains show the Dho-phase over wide temperature ranges.Of some selected new thioethers 3, sulfones 4, and of the sulfoxide 5f the dipole moments have been measured which are highest with the cyano derivatives 3g and 4g at about 5 or above 6 D, respectively.These values characterize them as the strongest polar discogens studied so far.The presented monothioscyllitol derivatives 3, 4 and 5 do not only increase the number of rarely known polar discogens, but also show that non-centrosymmetric and polar discotic liquid crystals with a small, alimonocyclic, saturated "core" now can be prepared easily.Their permanent electric dipole moments could give rise to interesting magnetic or electric field effects. - Inositols, Cyclohexane Derivatives, Discogenes, Discophases, Dipole Moments