Porphyrins with Exocyclic Rings. Part 8 [1], Synthesis of Nitrogen-15 and Carbon-13 Labeled 2,3:7,8:12,13:17,18-Tetrabutanoporphyrin [2,3]

Article abstract of DOI:10.1002/jhet.5570340141

Nitrogen-15 labeled butyl 4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate was prepared via butyl isocyanoacetate from ¹⁵N-glycine in an overall 46% yield, This bicyclic intermediate was converted into nitrogen-15 and carbon-13 labeled 2,3:7,8:12, 13:17, 18-tetrabutanoporphyrin, a useful model system for the sedimentary tetrahydrobenzoporphyrins.