51676-74-5

Usage

Uses

1. Chemical Synthesis:
5-CHLORO-2,4-DINITROTOLUENE is used as a chemical intermediate for the synthesis of 5-methyl-6-nitrobenzofuroxan, a compound with potential applications in various industries.
2. Analytical Chemistry:
In the field of analytical chemistry, 5-CHLORO-2,4-DINITROTOLUENE is used for the development of molecular imprinted polymer (MIP) based electrochemical impedimetric sensors. These sensors have been found to have a low-detection-limit of 0.1μM for 5CDNT, making them highly sensitive and useful for detecting trace amounts of the compound in various samples.
3. Environmental and Industrial Applications:
Although not explicitly mentioned in the provided materials, 5-CHLORO-2,4-DINITROTOLUENE may also have potential applications in environmental monitoring and industrial processes due to its chemical properties. For instance, it could be used in the detection and analysis of pollutants or as a component in the manufacturing of certain chemicals or materials.

InChI:InChI=1/C7H5ClN2O4/c1-4-2-5(8)7(10(13)14)3-6(4)9(11)12/h2-3H,1H3

Upstream product

• 108-41-8 1-chloro-3-methylbenzene 
• 4395-80-6 2-chloro-1-isopropyl-4-methyl-benzene 
• 5267-27-6 5-amino-2,4-dinitrotoluene 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 2028-72-0 m-toluenediazonium chloride 
• 90649-68-6 1-(2-chloro-4-methylphenyl)ethan-1-one 
• 610-25-3 2,4,5-trinitrotoluene 

Downstream Products

• 861544-73-2 (5-methyl-2,4-dinitro-phenyl)-malonic acid diethyl ester 
• 107410-42-4 5-methyl-6-nitro-2-p-tolyl-2H-benzotriazole 
• 260410-77-3 1-(5-methyl-2,4-dinitro-phenyl)-piperidine 
• 343620-45-1 2-(5-methyl-2,4-dinitro-phenyl)-acetoacetic acid ethyl ester 
• 1084-17-9 1-chloro-3-methyl-2,4,6-trinitrobenzene 
• 616-73-9 4,6-dinitro-3-hydroxytoluene 
• 52062-84-7 bis-(5-methyl-2,4-dinitro-phenyl)-disulfide 
• 5267-27-6 5-amino-2,4-dinitrotoluene 
• 43216-72-4 2,4-diamino-5-chlorotoluene 
• 34648-99-2 4-chloro-2-methyl-5-nitroaniline 
• 101257-15-2 5-iodo-2,4-dinitro-toluene 
• 5267-23-2 (5-methyl-2,4-dinitro-phenyl)-hydrazine 
• 136833-36-8 5-chloro-2,4-dinitrobenzoic acid 
• 56223-99-5 4.6-dinitro-4'-oxy-3-methyl-diphenylamine 

Relevant academic research and scientific papers

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Modulators of ATP-binding cassette transporters

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Synthesis of the Food Mutagens MeIQx and 4,8-DiMeIQx by Copper(I) Promoted Quinoxaline Formation

The regiocontrolled syntheses of the title compounds (1 and 2) is described.The key step is a new intramolecular alkyne amination and aromatization process (5 6; 8 9) effected by tetrakis(acetonitrile)copper(I) tetrafluoroborate.