51676-74-5

Basic information

• Product Name: 5-CHLORO-2,4-DINITROTOLUENE
• Synonyms: 5-CHLORO-2,4-DINITROTOLUENE;1-CHLORO-5-METHYL-2,4-DINITROBENZENE;3-Chloro-4,6-dinitrotoluene;1-Chloro-2,4-dinitro-5-methylbenzene, 4,6-Dinitro-m-tolyl chloride
• CAS NO: 51676-74-5
• Molecular Formula: C₇H₅ClN₂O₄
• Molecular Weight: 216.58
• Product Categories: Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 51676-74-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 87-91 °C(lit.)
• Boiling Point: 334 °C at 760 mmHg
• Flash Point: 155.8 °C
• Appearance: /
• Density: 1.532 g/cm³
• Vapor Pressure: 0.000255mmHg at 25°C
• Refractive Index: 1.61
• BRN: 2506591
• CAS DataBase Reference: 5-CHLORO-2,4-DINITROTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2,4-DINITROTOLUENE(51676-74-5)
• EPA Substance Registry System: 5-CHLORO-2,4-DINITROTOLUENE(51676-74-5)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 51676-74-5(Hazardous Substances Data)

Usage

Uses

5-Chloro-2,4-dinitrotoluene (5CDNT) may be used to synthesize 5-methyl-6-nitrobenzofuroxan.

General Description

A molecular imprinted polymer (MIP) based electrochemical impedimetric sensor has been fabricated for the sensitive determination of 5CDNT. Low-detection-limit of 5CDNT was observed to be 0.1μM using this sensor.

InChI:InChI=1/C7H5ClN2O4/c1-4-2-5(8)7(10(13)14)3-6(4)9(11)12/h2-3H,1H3

Upstream product

• 4395-80-6 2-chloro-1-isopropyl-4-methyl-benzene 
• 610-25-3 2,4,5-trinitrotoluene 
• 2028-72-0 m-toluenediazonium chloride 
• 90649-68-6 1-(2-chloro-4-methylphenyl)ethan-1-one 
• 7697-37-2 nitric acid 
• 5267-27-6 5-amino-2,4-dinitrotoluene 
• 108-41-8 1-chloro-3-methylbenzene 
• 7664-93-9 sulfuric acid 

Downstream Products

• 53827-45-5 (5-methyl-2,4-dinitro-phenylsulfanyl)-acetic acid 
• 854252-72-5 (5-methyl-2,4-dinitro-phenyl)-m-tolyl-amine 
• 107456-20-2 5-methyl-6-nitro-2-p-tolyl-2H-benzotriazole-1-oxide 
• 68142-49-4 5-benzylidene-3-(5-methyl-2,4-dinitro-phenyl)-2-thioxo-thiazolidin-4-one 
• 861347-99-1 N-(5-methyl-2,4-dinitro-phenyl)-o-phenylenediamine 
• 3606-21-1 5-methoxy-2,4-dinitrotoluene 
• 57221-29-1 p-Chlorophenyl-3-methyl-4,6-dinitrophenyl-sulfid 
• 861318-76-5 N-(5-methyl-2,4-dinitro-phenyl)-p-phenylenediamine 
• 67419-82-3 N-benzyl-5-methyl-2,4-dinitro-aniline 
• 110030-57-4 N-(5-methyl-2,4-dinitro-phenyl)-N'-phenyl-hydrazine 
• 14393-63-6 2-(5-methyl-2,4-dinitro-phenylsulfanyl)-aniline 
• 73418-68-5 (5-methyl-2,4-dinitro-phenyl)-phenyl-amine 
• 93431-77-7 (2-methoxy-phenyl)-(5-methyl-2,4-dinitro-phenyl)-amine 

Relevant articles and documents

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Modulators of ATP-binding cassette transporters

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.