51688-29-0

Upstream product

• 858202-28-5 N-hexyl-4-(4-nitro-benzenesulfonyl)-aniline 
• 51688-38-1 hexanoic acid-(4-sulfanilyl-anilide) 
• 638-45-9 1-Iodohexane 
• 142-61-0 Hexanoyl chloride 
• 51688-36-9 hexanoic acid-[4-(4-nitro-benzenesulfonyl)-anilide] 
• 1948-92-1 4-(4-nitrophenylsulfonyl)aniline 
• 859792-55-5 toluene-4-sulfonic acid-[N-hexyl-4-(4-nitro-benzenesulfonyl)-anilide] 
• 111453-03-3 4'-nitro-4-N-tosylaminodiphenyl sulfide 
• 123862-11-3 N-[4-(4-Hexylamino-benzenesulfonyl)-phenyl]-acetamide 
• 1775-37-7 N-[4-(4-Nitro-benzenesulfonyl)-phenyl]-acetamide 
• 7467-51-8 4-acetylamino-4'-nitrodiphenyl sulfide 
• 565-20-8 monoacetyldapsone 

Relevant academic research and scientific papers

Studies on 2,3,N,N'-substituted 4,4'-diaminodiphenylsulfones as potential antimalarial agents

A series of new 4,4'-diaminodiphenylsulfones substituted at 2 and 3 position and also at primary amino group of the phenyl rings have been synthesised and evaluated for their antimalarial activity against Plasmodium berghei infection in mice. Some of these compounds were active and showed complete inhibition of parasitaemia which included 7a1-7a4, 7b3, 7b4 and 16a at 1 mg/kg i.p. for 4 days and 16a, at 0.3 mg/kg for 4 days. Some compounds tested for their synthetase inhibitory action in cell-free system isolated from P. berghei (7b1, 7b2 and 8b2) were found to be more active than diaminodiphenylsulphone. The difference in order of activity between these in vivo and in vitro tests may be due to differences in their pharmacokinetic properties.

Potential antileprotic agents. I. Inhibition of a model mycobacterial system by diaryl sulfones

The development of a new antileprotic agent poses particular problems in view of the fact that the etiological agent of human leprosy, Mycobacterium leprae, cannot be cultured in bacteriological media. However, a correlation has been observed between mini