517-04-4 Usage
Uses
Used in Pharmaceutical Applications:
(8α)-Estradiol is used as a hormone replacement therapy for managing menopausal symptoms, such as hot flashes and vaginal dryness. It helps alleviate the discomfort and improves the quality of life for postmenopausal women.
Used in Orthopedic Applications:
(8α)-Estradiol is used as a treatment for postmenopausal osteoporosis to help prevent bone loss and reduce the risk of fractures. It supports bone health and maintains bone density in women experiencing menopause.
Used in Oncology:
(8α)-Estradiol is used as a targeted therapy for certain types of breast cancer, particularly those that are hormone receptor-positive. It can help control tumor growth and improve patient outcomes when used in combination with other cancer treatments.
Used in Neuroprotection and Anti-Inflammatory Applications:
(8α)-Estradiol is being studied for its potential neuroprotective effects, which may help protect the brain from damage and degeneration. It is also being investigated for its anti-inflammatory properties, which could be beneficial in treating various inflammatory conditions.
Used in Cognitive Function and Mood Regulation:
(8α)-Estradiol is used as a therapeutic agent for its potential role in cognitive function and mood regulation. It may help improve memory, learning, and emotional well-being, particularly in postmenopausal women experiencing cognitive decline or mood disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 517-04-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 7 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 517-04:
(5*5)+(4*1)+(3*7)+(2*0)+(1*4)=54
54 % 10 = 4
So 517-04-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15+,16+,17+,18+/m1/s1
517-04-4Relevant academic research and scientific papers
A Total Synthesis of Estradiol and its 6,6-Dimethyl Analogue
Collins, Mark A.,Jones, D. Neville
, p. 4467 - 4470 (2007/10/02)
A short, stereoselective synthesis of estradiol, and its 6,6-dimethyl analogue, was accomplished from non-steroidal starting materials.A key feature was the use of a benzothiophene unit to effect (i) the stereoselective formation of the required 8β-H c
