5176-12-5

Basic information

• Product Name: (2-NITRO-PHENYL)-PHENYL-METHANOL
• Synonyms: (2-NITRO-PHENYL)-PHENYL-METHANOL
• CAS NO: 5176-12-5
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.23134
• Mol File: 5176-12-5.mol
• Article Data: 20

Chemical Properties

• Melting Point: 59-60 °C
• Boiling Point: 420.9°C at 760 mmHg
• Flash Point: 181.2°C
• Appearance: /
• Density: 1.281g/cm³
• Vapor Pressure: 7.73E-08mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.96±0.20(Predicted)
• CAS DataBase Reference: (2-NITRO-PHENYL)-PHENYL-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2-NITRO-PHENYL)-PHENYL-METHANOL(5176-12-5)
• EPA Substance Registry System: (2-NITRO-PHENYL)-PHENYL-METHANOL(5176-12-5)

Safety Data

• Hazardous Substances Data: 5176-12-5(Hazardous Substances Data)

Usage

General Description

(2-Nitro-phenyl)-phenyl-methanol, also known as 2-nitro-diphenylmethanol, is a chemical compound with the molecular formula C13H11NO3. It is a white to light yellow crystalline powder that is used in the synthesis of pharmaceuticals and organic compounds. It is a derivative of phenylmethanol and contains a nitro group, which can have various chemical reactions and applications. The compound may have potential applications in the fields of medicine, pharmaceuticals, and organic chemistry due to its structural and chemical properties. However, it is important to handle and use this chemical with caution, following proper safety measures and regulations, as it may have potential hazards and risks associated with its use.

InChI:InChI=1/C13H11NO3/c15-13(10-6-2-1-3-7-10)11-8-4-5-9-12(11)14(16)17/h1-9,13,15H

Upstream product

• 934-56-5 trimethyl(phenyl)stannane 
• 552-89-6 2-nitro-benzaldehyde 
• 98-80-6 phenylboronic acid 
• 108-86-1 bromobenzene 
• 100-58-3 phenylmagnesium bromide 
• 609-73-4 o-nitroiodobenzene 
• 100-52-7 benzaldehyde 
• 76847-20-6 2-Nitro-1-benzol 

Downstream Products

• 13209-38-6 (2-aminophenyl)(phenyl)methanol 
• 1229610-04-1 2-(4-chloro-phenyl)-4-phenyl-quinazoline 
• 31730-65-1 2,4-diphenylquinazoline 
• 5782-11-6 2-(4-methoxyphenyl)-3-phenyl-1H-indole 

Relevant articles and documents

Photo-Induced N-N Coupling of o-Nitrobenzyl Alcohols and Indolines to Give N-Aryl-1-amino Indoles

A novel method to synthesize N-aryl-1-amino indoles was established by the photoinduced N-N coupling reaction. This protocol is by treatment of o-nitrobenzyl alcohols and indolines in the presence of TEAI and acetic acid with a 24 W ultraviolet (UV) light

Intramolecular addition of diarylmethanols to imines promoted by KO: T -Bu/DMF: A new synthetic approach to indole derivatives

KOt-Bu/DMF promoted intramolecular addition of diarylmethanols to imines was developed. A series of 2,3-disubstituted indoles was obtained in good yields. A reaction mechanism of radical cyclization and subsequent dehydration is proposed.

Validation of PqsD as an anti-biofilm target in pseudomonas aeruginosa by development of small-molecule inhibitors

2-Heptyl-4-hydroxyquinoline (HHQ) and Pseudomonas quinolone signal (PQS) are involved in the regulation of virulence factor production and biofilm formation in Pseudomonas aeruginosa. PqsD is a key enzyme in the biosynthesis of these signal molecules. Using a ligand-based approach, we have identified the first class of PqsD inhibitors. Simplification and rigidization led to fragments with high ligand efficiencies. These small molecules repress HHQ and PQS production and biofilm formation in P. aeruginosa. This validates PqsD as a target for the development of anti-infectives.