5410-05-9Relevant academic research and scientific papers
Unmodified Fe3O4 nanostructure promoted with external magnetic field: safe, magnetically recoverable, and efficient nanocatalyst for N- and C-alkylation reactions in green conditions
Rafiee, Ezzat,Joshaghani, Mohammad,Abadi, Parvaneh Ghaderi-Shekhi
, p. 2503 - 2522 (2018/01/04)
Transition metal compounds have emerged as suitable catalysts for organic reactions. Magnetic compounds as soft Lewis acids can be used as catalysts for organic reactions. In this report, the Fe3O4 nanostructures were obtained from Fe2+ and Fe3+-salts, under an external magnetic field (EMF) without any protective agent. The X-ray photoelectron spectroscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy tools were used to characterize these magnetic compounds. The two-dimensional (2-D, it showed nanometric size in the two dimensions, nanorod structure) Fe3O4 compound showed high catalytic activity and stability in N- and C-alkylation reactions. A diverse range of N- and C-alkylation products were obtained in moderate to high yield under green and mild conditions in air. Also the N- and C-alkylation products can be obtained with different selectivity and yield by exposure reactions with EMF. Results of alkylation reactions showed that the presence of Fe(II) and Fe(III) species on the surface of magnetic catalysts (phase structure of magnetic compounds) are essential as very cheap active sites. Also, morphology of magnetic catalysts had influence on their catalytic performances. After the reaction, the catalyst/product(s) separation could be easily achieved with an external magnet and more than 95% of catalyst could be recovered. The catalyst was reused at least four times without any loss of its high catalytic activity for N- and C-alkylation reactions.
An Efficient Ga(OTf)3/Isopropanol Catalytic System for Direct Reduction of Benzylic Alcohols
Sai, Masahiro
, p. 4330 - 4335 (2018/10/15)
This study aims to report the first gallium-catalyzed direct reduction of benzylic alcohols using isopropanol as a reductant. The reaction proceeds via gallium catalyst-assisted hydride transfer of the in situ-generated benzylic isopropyl ether. The method generates only water and acetone as byproducts and thus provides an atom-economic and environmentally friendly approach to the synthesis of di- and triarylmethanes, which are important substructures in various bioactive compounds and functional materials. (Figure presented.).
Copper-mediated arylation with arylboronic acids: Facile and modular synthesis of triarylmethanes
Rao, H. Surya Prakash,Rao, A. Veera Bhadra
supporting information, p. 496 - 504 (2016/04/05)
A facile and modular synthesis of triarylmethanes was achieved in good yield via a two-step sequence in which the final step is the copper(II)-catalyzed arylation of diarylmethanols with arylboronic acids. By using this protocol a variety of symmetrical and unsymmetrical triarylmethanes were synthesized. As an application of the newly developed methodology, we demonstrate a highyielding synthesis of the triarylmethane intermediate towards an anti-breast-cancer drug candidate.
Microwave-assisted nafion-H catalyzed friedel-crafts type reaction of aromatic aldehydes with arenes: Synthesis of triarylmethanes
Prakash, Surya G. K.,Fogassy, Gabriella,Olah, George A.
experimental part, p. 155 - 159 (2011/01/04)
A new solid acid Nafion-H, a perfluorinated sulfonic acid resin, catalyzed microwave-assisted synthesis of triarylmethanes is described. Various benzaldehydes react readily with arenes to provide the corresponding triarylmethanes in good to excellent yields. The reactions were carried out under solvent free conditions under microwave irradiation in a pressure vessel. The solvent free microwave irradiation methods appears to be an environmentally friendly synthetic protocol providing products in significantly shorter reaction times over traditional heating methods carried out in a pressure tube.
BF3-H2O catalyzed hydroxyalkylation of aromatics with aromatic aldehydes and dicarboxaldehydes: Efficient synthesis of triarylmethanes, diarylmethylbenzaldehydes, and anthracene derivatives
Prakash, G. K. Surya,Panja, Chiradeep,Shakhmin, Anton,Shah, Eric,Mathew, Thomas,Olah, George A.
supporting information; experimental part, p. 8659 - 8668 (2009/12/30)
(Figure Presented) BF3-monohydrate is found to be an efficient and strong acid catalyst as well as an effective protosolvating medium suitable for the hydroxyalkylation of arenes with aromatic aldehydes. This reaction has been extended to aromatic dialdehydes, such as terephthalic dicarboxaldehyde and isoterephthalic dicarboxaldehyde, for the efficient synthesis of diarylmethylbenzaldehydes, which are useful synthons for various organic transformations. Further, successful one step convergent synthesis of various synthetically useful anthracene derivatives from phthalaldehyde was also achieved. BF3-H2O is less expensive and acts as an efficient substitute for nonoxidizing strong protic acids/superacids.
C-F Activation of hydrofluorocarbons (HFCs) mediated by aluminum reagents
Ali, Majeid,Liu, Le-Ping,Hammond, Gerald B.,Xu, Bo
scheme or table, p. 4078 - 4080 (2009/10/11)
In the presence of various aluminum reagents, the difluoromethylene group (CF2) in selected hydrofluorocarbons (HFCs) undergoes a Friedel-Crafts type reaction with aromatic compounds in satisfactory yields.
A MILD REDUCTION OF BENZYL ALCOHOLS WITH DIPHOSPHORUS TETRAIODIDE
Suzuki, Hitomi,Tani, Hiroyuki,Kubota, Hirohisa,Sato, Naofumi,Tsuji, Junko,Osuka, Atsuhiro
, p. 247 - 248 (2007/10/02)
On treatment with diphosphorus tetraiodide in boiling benzene, benzyl alcohols are smoothly reduced to parent hydrocarbons in good to moderate yields.
