51788-81-9Relevant academic research and scientific papers
Native Amine-Directed ortho -C-H Halogenation and Acetoxylation /Condensation of Benzylamines
Chand-Thakuri, Pratibha,Alahakoon, Indunil,Liu, Daniel,Kapoor, Mohit,Kennedy, John F.,Jenkins, Kenneth W.,Rabon, Allison M.,Young, Michael C.
, p. 341 - 354 (2021/10/07)
Free or unfunctionalized benzylamines are well known to participate in C-H activation in the presence of palladium salts. Despite the ease with which these complexes can be activated, subsequent functionalization of the dimeric cyclometalates can be chall
ARYL AND HETEROARYL ETHER COMPOUNDS AS ROR GAMMA MODULATORS
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Page/Page column 47; 48; 49, (2015/11/09)
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, R, R2, R3, n, and p are as defined herein, which are active as modulators of retinoid-related orpha
AZETIDINES AND CYCLOBUTANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS
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Page/Page column 71-72, (2010/01/29)
The invention relates to compounds of formula (I) wherein R, R0, R1, m, n and X1 to X4 have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.
The lithiation of fluorinated benzenes and its dependence on solvent and temperature
Coe, Paul Leslie,Waring, Anthony John,Yarwood, Thomas David
, p. 2729 - 2738 (2007/10/02)
The formation of lithio derivatives from fluorinated benzenes and fluorinated bromobenzenes has been studied.The bases used were lithium diisopropylamide (LDA) in THF-hexane, butyllithium in diethyl ether-hexane and butyllithium in THF-hexane.The lithiated intermediates have been trapped using acetone, to form fluorinated 2-arylpropan-2-ols, or have been warmed to produce benzynes which have trapped by furan in Diels-Alder additions.The use of LDA allows clean removal of the most acidic proton in the aromatic ring: butyllithium in ether-hexane brings about clean bromine-lithium exchange.In constrast, the use of butyllithium in THF-hexane at -78 deg C results in autometallation and the formation of more complex product mixtures.For the formation of the benzynes involved in the Diels-Alder reactions it is necessary to warm the reaction mixtures.When ether-hexane is used as solvent the reactions remain fairly clean, but when THF is added the increasing autometallation again results in more complex reaction mixtures.
