51876-00-7

Upstream product

• 3360-54-1 3-bromo-2-phenylprop-1-ene 
• 122-52-1 triethyl phosphite 
• 683-08-9 Diethyl methylphosphonate 
• 5155-87-3 3-phenylbut-3-enoic acid 
• 762-04-9 phosphonic acid diethyl ester 
• 222180-54-3 diethyl [2-phenyl-2-(2-tosylhydrazono)ethyl]phosphonate 
• 74-88-4 methyl iodide 
• 108-86-1 bromobenzene 
• 222180-52-1 diethyl (E)-[2-(2-tosylhydrazono)propyl]phosphonate 
• 41849-03-0 diethoxyphosphorylmethyl-lithium 
• 187975-82-2 diethyl 2-hydroxy-2-phenylpropylphosphonate 

Downstream Products

• 255711-84-3 diethyl (S)-(2-phenylpropyl)phosphonate 
• 31378-03-7 1-phenyl-2-tosylethanone 

Relevant academic research and scientific papers

Copper-Catalyzed Decarboxylative Functionalization of Conjugated β, Γ-Unsaturated Carboxylic Acids

Copper-catalyzed decarboxylative coupling reactions of conjugated β,γ-unsaturated carboxylic acids have been achieved for allylic amination, alkylation, sulfonylation, and phosphinoylation. This approach was effective for a broad scope of amino, alkyl, su

Palladium-Catalyzed Olefination of N-Tosylhydrazones as β-Diazo Phosphonate Precursors with Arylhalides

An efficient palladium-catalyzed olefination of N-tosylhydrazones as β-diazo phosphonate precursors with aryl halides has been developed. 2,2-Disubstituted vinylphosphonates bearing versatile functional groups were easily accessed in moderate to excellent

Highly enantioselective Rh-catalyzed hydrogenation of β,γ- unsaturated phosphonates with chiral ferrocene-based monophosphoramidite ligands

(Chemical Equation Presented) An enantioselective synthesis of chiral alkylphosphonates bearing a β-stereogenic center, based on the Rh-catalyzed asymmetric hydrogenation of corresponding β-substituted β,γ-unsaturated phosphonates with a ferrocene-based monophosphoramidite ligand under the mild hydrogenation conditions, was developed, in which an ee value of up to 98% was obtained.

Synthesis of chiral γ-amino-β-hydroxyphosphonate derivatives from unsaturated phosphonates

γ-Amino-β-hydroxyphosphonates, useful intermediates for the synthesis of phosphonic acid analogues of carnitine, were prepared as their protected derivatives in an enantioselective manner from β,γ- unsaturated phosphonates through asymmetric dihydroxylati

A convenient (E)-stereoselective synthesis of alkenylphosphonates

Diethyl (E)-alkenylphosphonates have been prepared stereoselectively by dehydration of the corresponding β-hydroxyphosphonates using DCC/CuCl2 in refluxing toluene. Starting β-hydroxyphosphonates were obtained in high yield from diethyl methylphosphonate.