51925-38-3

Upstream product

• 51925-38-3 (1SR,2SR)-2-n-butylaminocyclohexanol 
• 38898-70-3 cis-2-amino-cyclohexanol-⁽¹⁾ 
• 123-72-8 butyraldehyde 
• 109-65-9 1-bromo-butane 
• 931-16-8 (+/-)-trans-2-aminocyclohexanol 
• 286-20-4 cyclohexane-1,2-epoxide 
• 109-73-9 N-butylamine 

Downstream Products

• 1071658-43-9 (1R)-trans-2-Butylamino-cyclohexanol-⁽¹⁾ 
• 51925-38-3 (1S)-trans-2-Butylamino-cyclohexanol-⁽¹⁾ 
• 87767-71-3 3-n-butyl-1-(2-chloroethyl)-3-(trans-2-hydroxycyclohexyl)urea 
• 87785-46-4 2-(n-butyl-(trans-2-hydroxycyclohexyl)amino)oxazoline 
• 87767-88-2 Acetic acid (1R,2R)-2-[butyl-(4,5-dihydro-oxazol-2-yl)-amino]-cyclohexyl ester 
• 87767-81-5 C₁₃H₂₄ClN₃O₃ 

Relevant academic research and scientific papers

Quaternary ammoniums and a cationic sodium complex as supramolecular catalysts in ring-opening of epoxides by amines

Supramolecular ionic organocatalysts and a metal-based catalyst were investigated in the ring-opening of epoxides by amines, without any artifice to enhance conversion (i.e., solvophobic effect, extended reaction time, heating, excess of amine, high catalyst loading). Different β-amino-alcohols were obtained in satisfying conversion (50-80%) in 24 h, under mild conditions.

Regioselective ring-opening of epoxides with amines using Zn(ClO4)2-Al2O3 as a heterogeneous and recyclable catalyst

A simple and efficient method has been developed for the synthesis of β-amino alcohols by regioselective ring-opening of epoxides with amines in the presence of zinc perchlorate-neutral alumina as a heterogeneous recyclable catalyst at room temperature in high yields.

Highly chemoselective addition of amines to epoxides in water

(Chemical Equation Presented) Aminolysis of a variety of epoxides by aliphatic and aromatic amines in water, in the absence of any catalyst with high yields, is reported. β-Amino alcohols were formed under mild conditions with high selectivity and in excellent yields.

Transition metal-based lewis acid catalyzed ring opening of epoxides using amines under solvent-free conditions

Transition metal-based Lewis acids, such as SnCl4·5H 2O, Co(OAc)2·4H2O, Ni(OAc) 2·2H2O, NiCl2, Mn(OAc) 2·4H2O etc. catalyze the nucleophilic opening of epox

Zirconium sulfophenyl phosphonate as a heterogeneous catalyst in the preparation of β-amino alcohols from epoxides

A convenient method for the ring opening of epoxides by aromatic amines, catalysed by zirconium sulfophenyl phosphonate in solvent-free conditions, is described.

Diisopropoxyaluminium trifluoroacetate: A new promoter for aminolysis of epoxides

Aminolysis of symmetrical as well as unsymmetrical epoxides using various amines in the presence of diisopropoxyaluminium trifluoroacetate (DIPAT) as a new promoter gave 1,2-amino alcohols in excellent yields at room temperature with good to excellent selectivities.

A new class of nitrosoureas. VIII. Synthesis and antitumor activity of 3-substituted 1-(2-chloroethyl)-3-(trans-2-hydroxy-cyclohexyl)-1-nitrosoureas

A series of six 3-substituted 1-(2-chloroethyl)-3-(trans-2-hydroxycyclohexyl)-1-nitrosoureas (IVa-f) was prepared and tested for antitumor activities. Heating of cyclohexene oxide with various alkylamines followed by reaction with 2-chloroethyl isocyanate