51964-15-9

Basic information

• Product Name: 4-Thiazolidinone, 3-(4-fluorophenyl)-2-[(4-fluorophenyl)imino]-
• CAS NO: 51964-15-9
• Molecular Formula: C15H10F2N2OS
• Molecular Weight: 304.32
• Mol File: 51964-15-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-Thiazolidinone, 3-(4-fluorophenyl)-2-[(4-fluorophenyl)imino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolidinone, 3-(4-fluorophenyl)-2-[(4-fluorophenyl)imino]-(51964-15-9)
• EPA Substance Registry System: 4-Thiazolidinone, 3-(4-fluorophenyl)-2-[(4-fluorophenyl)imino]-(51964-15-9)

Safety Data

• Hazardous Substances Data: 51964-15-9(Hazardous Substances Data)

Upstream product

• 404-52-4 N,N’-di-(4-fluorophenyl)thiourea 
• 105-39-5 chloroacetic acid ethyl ester 
• 371-40-4 4-fluoroaniline 
• 105-36-2 ethyl bromoacetate 
• 79-11-8 chloroacetic acid 
• 79-08-3 bromoacetic acid 

Downstream Products

• 51964-22-8 3-(4-fluoro-phenyl)-thiazolidine-2,4-dione 
• 52476-39-8 3-(4-fluoro-phenyl)-2-(4-fluoro-phenylimino)-thiazolidine-4,5-dione 5-(naphthalen-1-yl-hydrazone) 
• 52476-27-4 5-benzylidene-3-(4-fluoro-phenyl)-2-(4-fluoro-phenylimino)-thiazolidin-4-one 
• 52551-14-1 4-{[3-(4-fluoro-phenyl)-2-(4-fluoro-phenylimino)-4-oxo-thiazolidin-5-ylidene]-hydrazino}-benzenesulfonamide 
• 52476-36-5 3-(4-fluoro-phenyl)-2-(4-fluoro-phenylimino)-thiazolidine-4,5-dione 5-phenylhydrazone 
• 52476-48-9 3-(4-fluoro-phenyl)-2-(4-fluoro-phenylimino)-5-m-tolyl-thiazolidin-4-one 
• 52476-37-6 3-(4-fluoro-phenyl)-2-(4-fluoro-phenylimino)-thiazolidine-4,5-dione 5-o-tolylhydrazone 
• 678562-00-0 4-{5-[3-(4-Fluoro-phenyl)-2-[(Z)-4-fluoro-phenylimino]-4-oxo-thiazolidin-(5E)-ylidenemethyl]-furan-2-yl}-benzoic acid 
• 1352834-05-9 4-[3-(4-fluorophenyl)-2-(4-fluorophenylimino)-4-oxothiazolidin-5-ylidenemethyl]benzoic acid 
• 1352834-10-6 {4-[3-(4-fluorophenyl)-2-(4-fluorophenylimino)-4-oxothiazolidin-5-ylidenemethyl]phenoxy}acetic acid 
• 52476-34-3 3-(4-fluoro-phenyl)-2-(4-fluoro-phenylimino)-5-(2-hydroxy-benzylidene)-thiazolidin-4-one 
• 52476-38-7 3-(4-fluoro-phenyl)-2-(4-fluoro-phenylimino)-thiazolidine-4,5-dione 5-p-tolylhydrazone 
• 51963-96-3 3-[3-(4-fluoro-phenyl)-2-(4-fluoro-phenylimino)-4-oxo-thiazolidin-5-ylidene]-1,3-dihydro-indol-2-one 

Relevant articles and documents

Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I

A new series of 2-substituted imino-3-substituted-5- heteroarylidene-1,3-thiazolidine-4-ones as the potent bidentate PTP1B inhibitors were designed and synthesized in this paper. All of the new compounds were characterized and identified by spectra analysis. The biological screening test against PTP1B showed that some of these compounds have the positive inhibitory activity against PTP1B. The activity of the compounds with 5-substituted pyrrole on 5-postion of 1,3-thiazolidine-4-one are more potent than that of those compounds with 5-substituted pyridine group. Compound 14b, 14h and 14i showed IC50values of 8.66?μM, 6.83?μM and 6.09?μM against PTP1B, respectively. Docking analysis of these active compounds with PTP1B showed the possible interaction modes of these biheterocyclic compounds with the active sites of PTP1B. The inhibition tests against oncogenetic CDC25B were also conducted on this set of compounds to evaluate the selectivity and possible anti-neoplastic activity. Compound 14b also showed the lowest IC50of 1.66?μM against CDC25B among all the possible inhibitors, including 14g, 14h, 14i and 15c. Some pharmacological parameters including VolSurf, steric and electric descriptors of all the compounds were calculated to give some hints about the relative relationship with the biological activity. The result of this study might give some light on designing the possible anti-cancer drugs targeting at phosphatases. The most active compound 14i might be used as the lead compound for further structure modification of the new low molecular weight PTP1B inhibitors with the N-containing heterocyclic skeleton.

Synthesis and biological evaluation of 2-arylimino-3-pyridin-thiazolineone derivatives as antibacterial agents

With an intention to find more potent antibacterial agents, four halogen disubstituted thiazolineone derivatives (2a-d), five halogen monosubstituted thiazolineone derivatives (2e-i), and eleven 2-arylimino-3-pyridin-thiazolineone derivatives (2j-t) were

Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis

A series of novel substituted 4-thiazolidione derivatives were designed, synthesized, and evaluated in vitro for their antibacterial activities, in comparison with methicillin and ampicillin. Compounds (7d, 7h-k) exhibit good potency in inhibiting the growth of Staphylococcus epidermidis (MIC: 1.57-3.13 μM). Further antibacterial effects of compounds (7d, 7h-k) were investigated using clinical isolates (methicillin-resistant Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus), in comparison with methicillin and levofloxacin. Compound 7k showed the most potent antibacterial activities among the synthesized compounds.