51980-60-0Relevant articles and documents
Pyridine salt / 1,4-dihydropyridine derivative and preparation method thereof
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Paragraph 0102; 0104; 0105, (2016/10/09)
The present invention discloses a pyridine salt / 1,4-dihydropyridine derivative (NAD / NADH analog) with novel structure. The NAD / NADH analog can substitute natural NAD / NADH to be applied to a biochemical system for redox reactions, and can also be used as an electron carrier for the energy transfer of an enzymatic fuel cell. Further, the NAD / NADH analogs provided by the invention are easy to prepare, isolate and purify, and have a high yield.
Mesogen-jacketed liquid crystalline polymers substituted with oligo(oxyethylene) as peripheral chain
Liang, Xiaochao,Chen, Xiaofang,Li, Christopher Y.,Shen, Zhihao,Fan, Xinghe,Zhou, Qifeng
experimental part, p. 3693 - 3705 (2011/11/01)
Mesogen-jacketed liquid crystalline polymer (MJLCP) is a typical rod-shaped macromolecule. Its unique molecular architecture allows one to tune the geometric parameters of the macromolecular rod. Moreover, the rod surface chemistry can be controlled by de
Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs
Siddiqui, Adam,McGuigan, Christopher,Ballatore, Carlo,Srinivasan, Sheila,De Clercq, Erik,Balzarini, Jan
, p. 381 - 384 (2007/10/03)
A range of polyether para-substituted phosphoramidates were synthesised and found to have substantially elevated aqueous solubilities compared to the underivatised parent prodrug. A 30-fold increase in aqueous solubility could be achieved without a substantial decrease of in vitro activity against HIV-1. Replacement of the aryl (i.e. phenolic) moiety by tyrosine led to a substantial enhancement in aqueous solubility but also to a decrease in antiviral potency. A previously unobserved trend was identified, relating increased aryl substituent steric bulk to decreased antiviral activity. (C) 2000 Elsevier Science Ltd. All rights reserved.