51999-09-8

Basic information

• Product Name: acide phenyl-2 (methyl-4 phenyl)-2 hydroxy-2 ethanoique
• Synonyms: acide phenyl-2 (methyl-4 phenyl)-2 hydroxy-2 ethanoique
• CAS NO: 51999-09-8
• Molecular Weight: 242.274
• Mol File: 51999-09-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: acide phenyl-2 (methyl-4 phenyl)-2 hydroxy-2 ethanoique(CAS DataBase Reference)
• NIST Chemistry Reference: acide phenyl-2 (methyl-4 phenyl)-2 hydroxy-2 ethanoique(51999-09-8)
• EPA Substance Registry System: acide phenyl-2 (methyl-4 phenyl)-2 hydroxy-2 ethanoique(51999-09-8)

Safety Data

• Hazardous Substances Data: 51999-09-8(Hazardous Substances Data)

Upstream product

• 63007-15-8 trans-(4S,5S)-2-benzoyl-4-(methoxymethyl)-5-phenyl-2-oxazoline 
• 58635-82-8 (S,S)-2-benzyl-4-methoxymethyl-5-phenyl-2-oxazoline 
• 1042740-62-4 (R)-benzyl 2-hydroxy-2-(4-methylphenyl)-phenylacetate 
• 73713-24-3 (5S)-2-benzoyl-5-phenyl-2-oxazoline 
• 73713-23-2 (5S)-2-benzyl-5-phenyl-2-oxazoline 
• 127559-47-1 phenyl-2 (methyl-4 phenyl)-2 hydroxy-2 ethanoate de (-) menthyle 
• 73697-97-9 ((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-phenyl-p-tolyl-methanol 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 20229-41-8 l-menthyl phenylglyoxylate 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 4166-98-7 4-methylbenzilic acid 
• 120926-96-7 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methylphenyl)(oxo)acetate 

Downstream Products

• 1882-56-0 2-(4-methylphenyl)-2-phenylacetic acid 

Relevant articles and documents

Enantioselective rhodium-catalyzed addition of arylboronic acids to α-ketoesters

(Chemical Figure Presented) Rhodium catalysis: The first example of a catalytic asymmetric addition of arylboronic acids to α-ketoesters was realized by using a chiral RhI-spirophosphite ligand complex in aqueous solvent to provide tertiary α-hydroxyesters in good yields with high enantioselectivities (see scheme; DCE = 1,2-dichloroethane).

Asymmetric Addition of Organometallics to Chiral Ketooxazolines. Preparation of Enantiomerically Enriched α-Hydroxy Acids

Addition of Grignard and organolithium reagents to chiral α-ketooxazolines results in α-substituted α-hydroxyoxazoline derivatives which on hydrolytic removal of the chiral auxiliary groups give rise to α-substituted α-hydroxy acids in 30-87 percent enantiomeric excess (ee).Studies on the various parameters (solvents, temperature, substituents) were undertaken to reach optimum asymmetric induction.