52023-39-9

Upstream product

• 98-88-4 benzoyl chloride 
• 618-40-6 1-Methyl-1-phenylhydrazine 
• 532-96-7 N-benzoyl-N'-phenylhydrazine 
• 56-45-1 L-serin 
• 459-73-4 GlyOEt*HCl 
• 73-22-3 L-Tryptophan 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 100-61-8 N-methylaniline 
• 59259-48-2 C₁₄H₁₃BrN₂ 

Downstream Products

• 618-40-6 1-Methyl-1-phenylhydrazine 
• 65-85-0 benzoic acid 

Relevant academic research and scientific papers

Nitrene-mediated intermolecular N–N coupling for efficient synthesis of hydrazides

N–N linkages are found in many natural compounds and endow fascinating structural and functional properties. In comparison to the myriad methods for the construction of C–N bonds, chemistry for N–N coupling, especially in an intermolecular fashion, remains underdeveloped. Here, we report a nitrene-mediated intermolecular N–N coupling of dioxazolones and arylamines under iridium or iron catalysis. These reactions offer a simple and efficient method for the synthesis of various hydrazides from readily available carboxylic acid and amine precursors. Although the Ir-catalysed conditions usually give higher N–N coupling yield than the Fe-catalysed conditions, the reactions of sterically more demanding dioxazolones derived from α-substituted carboxylic acids work much better under the Fe-catalysed conditions. Mechanistic studies revealed that the nitrogen atom of Ir acyl nitrene intermediates has strong electrophilicity and can undergo nucleophilic attack with arylamines with the assistance of Cl···HN hydrogen bonding to form the N–N bond with high efficiency and chemoselectivity. [Figure not available: see fulltext.].

Synthesis method for intermolecular N-N bonding and corresponding synthesized compound

The invention relates to a synthesis method for intermolecular N-N bonding and a corresponding compound. According to the invention, the direct insertion reaction of N-H bonds by nitrene is completed, and a brand-new N-N coupling reaction method is developed. The reaction uses a nitrene precursor, under the action of a catalyst, an intermolecular direct N-N coupling reaction of the nitrene precursor and an amine compound can be realized, and a tetra-substituted hydrazine compound is constructed in one step.

Rh(III)-catalyzed oxidative coupling of 1,2-disubstituted arylhydrazines and olefins: A new strategy for 2,3-dihydro-1H-indazoles

A rhodium(III)-catalyzed oxidative olefination of 1,2-disubstituted arylhydrazines with alkenes via sp2 C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construct

N-aminoindoline derivatives as inhibitors of 5-lipoxygenase

N-Aminoindoline derivatives were prepared and their 5-lipoxygenase inhibitory activities were evaluated in vitro and compared with those of phenidone and NDGA. Compound 4 presents the most effective 5-LO inhibition.