59950-50-4

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 5-amino-2-chloropyrimidine-4-carboxylate is used as an intermediate in the production of various drugs. Its molecular structure allows for the synthesis of a wide range of pharmaceutical compounds, making it a valuable component in the development of new medications.
Used in Agrochemical Industry:
In the agrochemical industry, ethyl 5-amino-2-chloropyrimidine-4-carboxylate is utilized as a key intermediate in the synthesis of pesticides. Its reactivity and molecular structure contribute to the creation of effective pest control agents, enhancing crop protection and yield.
Used in Chemical Synthesis:
Ethyl 5-amino-2-chloropyrimidine-4-carboxylate is used as a versatile building block in chemical synthesis. Its unique functional groups enable the formation of various chemical compounds, making it a valuable asset in the development of new chemical products across different industries.

Upstream product

• 65-86-1 orotic acid 
• 17687-24-0 5-nitroorotic acid 
• 52047-16-2 ethyl 5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate 
• 54368-61-5 ethyl 2,4-dichloro-5-nitro-6-pyrimidinecarboxylic acid 

Downstream Products

• 189747-29-3 5-amino-2-chloropyrimidine-4-carboxamide 
• 59950-51-5 5-amino-pyrimidine-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

NITROGEN HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparing the compounds, compositions comprising the compounds, and methods of using the compounds as inhibitors of receptor tyrosine kinases, in particular oncogenic mutants of ErbB-receptors e.g. in the treatment of cancer.

Method for synthesizing 2-chloro-5-amino-6-pyrimidine ethyl formate

The invention discloses a method for synthesizing 2-chloro-5-amino-6-pyrimidine ethyl formate. The method comprises the following steps: firstly, enabling fuming nitric acid, concentrated sulfuric acid and orotic acid to react so as to obtain nitroorotic acid; further mixing the obtained nitroorotic acid with ethanol, and adding dropwise the concentrated sulfuric acid at room temperature so as toobtain nitroorotic acid ethyl ester; enabling the nitroorotic acid ethyl ester to react with phosphorus oxychloride and an organic alkali so as to obtain 2,4-dichloro-5-nitro-6-pyrimidine ethyl formate; and finally mixing the 2,4-dichloro-5-nitro-6-pyrimidine ethyl formate with palladium carbon and magnesium oxide, putting the mixture into tetrahydrofuran, and performing a reaction, so as to obtain a final product. By adopting the method, the orotic acid in the market is adopted as a raw material, and the 2-chloro-5-amino-6-pyrimidine ethyl formate is prepared through reactions of nitration, esterification, chlorination and reduction. The method is convenient in process operation, simple in operation, gentle in reaction and small in pollution, in addition, the prepared pyrimidine is high in yield and purity and small in environment pollution, and the prepared 2-chloro-5-amino-6-pyrimidine ethyl formate prepared by using the method can be applied to large-scale production.